Handbook of Statistics in Clinical Oncology

John J. Crowley is president and CEO of Cancer Research and Biostatistics (CRAB), Seattle, Washington, director of the SWOG Statistical Center, and a faculty member at the Fred Hutchinson Cancer Research Center. The author or coauthor of more than 350 refereed articles, book chapters, and other publications, Dr. Crowley is a fellow of the American Statistical Association and the American Association for the Advancement of Science and a member of the International Biometrics Society, the American Society for Clinical Oncology, and the International Association for the Study of Lung Cancer. He received his BA (1968) from Pomona College, Claremont, California, and his MS (1970) and PhD (1973) in biomathematics from the University of Washington, Seattle. Antje Hoering, PhD, is a senior biostatistician at Cancer Research and Biostatistics (CRAB), Seattle, Washington. She is also an affiliate faculty member in the Department of Biostatistics at the University of Washington and an affiliate investigator at the Fred Hutchinson Cancer Research Center. Dr. Hoering is the lead statistician of the SWOG Myeloma Committee, the SWOG Early Therapeutics Subcommittee, and the Stand Up To Cancer, Pancreatic Dream Team. She is the coordinating statistician for the Myeloma Institute for Research and Therapy, the International Myeloma Committee, and the Pancreatic Cancer Research Team. She serves as a consultant on a variety of industry-sponsored studies and has been the biostatistics representative on two Type B meetings with the FDA. She is member of the American Statistical Association, the International Biometrics Society, and the International Myeloma Society. She received her BS (1985) from the University of Tubingen, Germany, her MS (1988) in physics from Oregon State University, Corvallis, and her PhD (1991) in physics from the Max Planck Institute for Theoretical Nuclear Physics, Heidelberg, Germany. She transitioned into biostatistics with a three-year NRSA postdoctoral fellowship with the Department of Biostatistics at the University of Washington and the Fred Hutchinson Cancer Research Center.

Choosing a Phase I Design. Dose Finding Designs Based on the Continual Reassessment Method. Pharmacokinetics in Clinical Oncology: Statistical Issues. Statistics of Phase 0 Trials. CRM Trials for Assessing Toxicity and Efficacy. Seamless Phase I/II Trial Design for Assessing Toxicity and Efficacy for Targeted Agents. Overview of Phase II Clinical Trials. Designs Based on Toxicity and Response. Designs Using Time to Event Endpoints/Single Arm versus Randomized Phase II. Phase II Selection Designs. Phase II with Multiple Subgroups: Designs Incorporating Disease Subtype or Genetic Heterogeneity. Phase II/III Designs. On Use of Covariates in Randomization and Analysis of Clinical Trials. Factorial Designs with Time to Event Endpoints. Early Stopping of Clinical Trials. Noninferiority Trials. Phase III Trials for Targeted Agents. Adaptive Trial Designs. Design of a Clinical Trial for Testing the Ability of a Continuous Marker to Predict Therapy Benefit. Software for Design and Analysis of Clinical Trials. Cure-Rate Survival Models in Clinical Trials. Design and Analysis of Quality of Life Data. Economic Analyses alongside Cancer Clinical Trials. Structural and Molecular Imaging in Cancer Therapy Clinical Trials. Prognostic Factor Studies. Predictive Modeling of Gene Expression Data. Explained Variation and Explained Randomness for Proportional Hazards Models. Prognostic Groups by Tree-Based Partitioning and Data Refinement Methods. Risk Calculators. Developing a Score Based upon Gene Expression Profiling and Validation. Analysis of DNA Microarrays. Methods for SNP Regression Analysis in Clinical Studies: Selection, Shrinkage, and Logic. Forensic Bioinformatics. Index.