A Combinatorial Chemistry Workbook

Combinatorial chemistry represents a revolution in the way the pharmaceutical industry identifies and optimizes leads for drugs. This text attempts to provide a basic knowledge and a practical guide to perform combinatorial chemistry as a tool for research. It deals with all aspects of the production of useful librairies of compounds for lead discovery and lead optimization, starting from the theoretical aspects of library design, though validation and synthesis of the library, to the analysis quality control of the products.