Pharmacokinetics and Toxicokinetics

Mehdi Boroujerdi is a professor of pharmaceutical sciences and the founding dean of the School of Pharmacy at the University of Massachusetts Lowell. He previously served as a professor, dean and provost of the Albany College of Pharmacy and Health Sciences in New York. He earned his PhD in pharmaceutics and pharmacokinetics from the University of North Carolina at Chapel Hill and conducted postdoctoral research at the National Institutes of Health – National Institute of Environmental Health Sciences (NIH-NIEHS) in chemical carcinogenesis and low-dose extrapolation. Dr. Boroujerdi has a broad background and experience in pharmacokinetics/toxicokinetics and the role of influx and efflux proteins. His current research explores the chemoresistance of pancreatic cancer cells to chemotherapeutic agents both in cell culture and in vivo. He has published more than 110 peer-reviewed articles as well as a textbook on pharmacokinetics, principles, and applications.

The Influence of Routes of Administration on ADME. Mechanisms of Absorption and Permeation of Xenobiotics. In Vivo Distribution of Xenobiotics. Elimination Rate, Clearance and the Theoretical Models. Renal Excretion of Xenobiotics and Estimation of Related PK/TK Parameters and Constants. Biotransformation of Xenobiotics. Kinetics of In Vitro Metabolism Assimilation of Intrinsic Clearance in Hepatic Clearance. Pharmaceutical, Biopharmaceutical, and Physiological Factors Influencing Oral Absorption of Xenobiotics-Mechanistic Absorption Models. Mathematical Modeling in Pharmacokinetics and Toxicokinetics.PK/TK Analysis of Instantaneous Exposure to Xenobiotics (Single Bolus Injection). PK/TK Analysis of Continuous Zero-Order Exposure to Xenobiotics (Intravenous Infusion). PK/TK Analysis of Xenobiotics Absorbed via an Extravascular Route of Administration (Oral Administration). PK/TK of Xenobiotics Absorbed through the Skin (Transdermal Absorption). PK/TK Analysis of Multiple Dosing. Bioavailability, Bioequivalence, and Biosimilar Evaluations. Preclinical PK/TK and Clinical Trials. Population Pharmacokinetics/Toxicokinetics. Quantitative Extrapolation Interspecies Scaling/Low Dose Extrapolation. Appendix A: Relevant Mathematical Concepts.