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Metabonomics

Methods and Protocols

Jacob T. Bjerrum (Herausgeber)

Buch | Hardcover

259 Seiten

2015
Humana Press Inc. (Verlag)
978-1-4939-2376-2 (ISBN)

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This volume on metabonomics provides detailed information on the procedures involved in nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectrometry (GS-MS), liquid chromatography-mass spectrometry (LC-MS), and capillary electrophoresis-mass spectrometry (CE-MS). Chapters focus on technologies and chemometrics, generation of metabonomics data, extraction of meaningful information from data, drug development, toxicology, diagnostics, and describing metabonomics as an essential part of systems biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Metabonomics - Analytical Techniques and Associated Chemometrics at a Glance.- Sample Collection and Preparation of Biofluids and Extracts for NMR Spectroscopy.- NMR Spectroscopy of Biofluids and Extracts.- High-resolution Magic-Angle-Spinning NMR Spectroscopy of Intact Tissue.- Sample Collection and Preparation of Biofluids and Extracts For Liquid Chromatography-Mass Spectrometry.- Liquid Chromatography-Mass Spectrometry of Biofluids and Extracts.- Sample Collection and Preparation of Biofluids and Extracts For Gas-Chromatography-Mass Spectrometry.- Gas Chromatography-Mass Spectrometry of Biofluids and Extracts.- Capillary Electrophoresis Mass Spectrometry.- Preprocessing of Raw Metabonomics Data.- Extracting Meaningful Information From Metabonomics Data Using Multivariate Statistics.- Combining Metabonomics and Other -omics Data.- The Strengths and Weaknesses of NMR Spectroscopy and Mass Spectrometry With Particular Focus on Metabolomics Research.- Metabonomics and Drug Development.- Metabonomics and Toxicology.- Metabonomics and Diagnostics.- Metabonomics and Systems Biology.

Reihe/Serie	Methods in Molecular Biology ; 1277
Zusatzinfo	48 Illustrations, color; 26 Illustrations, black and white; X, 259 p. 74 illus., 48 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	capillary electrophoresis-mass spectrometry (CE-MS) • Chemometrics • drug development • gas chromatography-mass spectrometry (GS-MS) • human metabonomics • liquid chromatography-mass spectrometry (LC-MS) • metabonomics data • nuclear magnetic resonance (NMR) spectroscopy
ISBN-10	1-4939-2376-5 / 1493923765
ISBN-13	978-1-4939-2376-2 / 9781493923762
Zustand	Neuware