Computational Modeling of Genetic and Biochemical Networks

Providing specific examples, this book examines how modelling techniques can be used to explore functionally relevant molecular and cellular relationships. The book is divided into two parts: models of gene activity and models of interactions among gene products.

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The advent of ever more sophisticated molecular manipulation techniques has made it clear that cellular systems are far more complex and dynamic than previously thought. At the same time, experimental techniques are providing an almost overwhelming amount of new data. It is increasingly apparent that linking molecular and cellular structure to function will require the use of new computational tools. This book provides specific examples, across a wide range of molecular and cellular systems, of how modelling techniques can be used to explore functionally relevant molecular and cellular relationships. The modelling techniques covered are applicable to cell, developmental, structural and mathematical biology; genetics and computational neuroscience. The book, intended as a primer for both theoretical and experimental biologists, is organised in two parts: models of gene activity and models of interactions among gene products. Modelling examples are provided at several scales for each subject. Each chapter includes an overview of the biological system in question and extensive references to important work in the area.