This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. - Logical information flow aids understanding of basic building blocks of life through disease phenotypes- Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns- Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation- Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
Contributors
Chapter 1
Roland Eils
Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany
Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany
Andres Kriete
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA
Chapter 2
Robert B. Russell
Cell Networks, University of Heidelberg, Heidelberg, Germany
Gordana Apic
Cell Networks, University of Heidelberg, Heidelberg, Germany
Olga Kalinina
Cell Networks, University of Heidelberg, Heidelberg, Germany
Leonardo Trabuco
Cell Networks, University of Heidelberg, Heidelberg, Germany
Matthew J. Betts
Cell Networks, University of Heidelberg, Heidelberg, Germany
Qianhao Lu
Cell Networks, University of Heidelberg, Heidelberg, Germany
Chapter 3
Hans V. Westerhoff
Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands
Manchester Centre for Integrative Systems Biology (MCISB), Manchester, UK
Fei He
Manchester Centre for Integrative Systems Biology (MCISB), Manchester, UK
Department of Automatic Control and Systems Engineering, The University of Sheffield, Sheffield, UK
Ettore Murabito
Manchester Centre for Integrative Systems Biology (MCISB), Manchester, UK
Frédéric Crémazy
Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
Matteo Barberis
Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
Chapter 4
Ursula Klingmüller
Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany
Marcel Schilling
Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany
Sonja Depner
Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany
Lorenza A. D’Alessandro
Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany
Chapter 5
Christina Kiel
EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Luis Serrano
EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
ICREA, Barcelona, Spain
Chapter 6
Seiya Imoto
Human Genome Center, Institute of Medical Science, The University of Tokyo, Minatoku, Tokyo, Japan
Hiroshi Matsuno
Faculty of Science, Yamaguchi University, Yoshida, Yamaguchi, Japan
Satoru Miyano
Human Genome Center, Institute of Medical Science, The University of Tokyo, Minatoku, Tokyo, Japan
Chapter 7
Hong-Wu Ma
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, P.R. China
School of Informatics, University of Edinburgh, Edinburgh, UK
An-Ping Zeng
Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestrasse, Germany
Chapter 8
Stanley Gu
Department of Bioengineering, University of Washington, Seattle, WA, USA
Herbert Sauro
Department of Bioengineering, University of Washington, Seattle, WA, USA
Chapter 9
Juergen Eils
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Elena Herzog
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Baerbel Felder
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany
Christian Lawerenz
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Roland Eils
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany
Chapter 10
Jean-Christophe Leloup
Unité de Chronobiologie théorique, Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, Brussels, Belgium
Didier Gonze
Unité de Chronobiologie théorique, Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, Brussels, Belgium
Albert Goldbeter
Unité de Chronobiologie théorique, Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, Brussels, Belgium
Chapter 11
Reinhard Laubenbacher
Virginia Bioinformatics Institute, Virginia Tech, Blacksburg VA, USA
Pedro Mendes
Virginia Bioinformatics Institute, Virginia Tech, Blacksburg VA, USA
School of Computer Science, The University of Manchester, Manchester, UK
Chapter 12
Joseph Xu Zhou
Institute for Systems Biology, Seattle, WA, USA
Xiaojie Qiu
Institute for Systems Biology, Seattle, WA, USA
Aymeric Fouquier d’Herouel
Institute for Systems Biology, Seattle, WA, USA
Sui Huang
Institute for Systems Biology, Seattle, WA, USA
Chapter 13
John Cole
University of Illinois at Urbana-Champaign, USA
Mike J. Hallock
University of Illinois at Urbana-Champaign, USA
Piyush Labhsetwar
University of Illinois at Urbana-Champaign, USA
Joseph R. Peterson
University of Illinois at Urbana-Champaign, USA
John E. Stone
University of Illinois at Urbana-Champaign, USA
Zaida Luthey-Schulten
University of Illinois at Urbana-Champaign, USA
Chapter 14
Jean-Luc Bouchot
Department of Mathematics, Drexel University, PA, Philadelphia, USA
William L. Trimble
Institute for Genomics and Systems Biology, Argonne National Laboratory, University of Chicago, Chicago, IL, USA
Gregory Ditzler
Department of Electrical and Computer Engineering, Drexel University, PA, Philadelphia, USA
Yemin Lan
School of Biomedical Engineering, Science and Health, Drexel University, PA, Philadelphia, USA
Steve Essinger
Department of Electrical and Computer Engineering, Drexel University, PA, Philadelphia, USA
Gail Rosen
Department of Electrical and Computer Engineering, Drexel University, PA, Philadelphia, USA
Chapter 15
Helder I Nakaya
Department of Pathology, Emory University, Atlanta, GA, USA
Vaccine Research Center, Emory University, Atlanta, GA, USA
Department of Clinical Analyses and Toxicology, University of Sao Paulo, Sao Paulo, SP, Brazil
Chapter 16
Julien Delile
Institut des Systèmes...
| Erscheint lt. Verlag | 26.11.2013 |
|---|---|
| Sprache | englisch |
| Themenwelt | Mathematik / Informatik ► Informatik ► Theorie / Studium |
| Medizin / Pharmazie ► Allgemeines / Lexika | |
| Naturwissenschaften ► Biologie | |
| Technik | |
| ISBN-10 | 0-12-405938-4 / 0124059384 |
| ISBN-13 | 978-0-12-405938-2 / 9780124059382 |
| Haben Sie eine Frage zum Produkt? |
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