Gene Network Inference

Verification of Methods for Systems Genetics Data

Alberto Fuente (Herausgeber)

Buch | Hardcover
XI, 130 Seiten
2014 | 2013
Springer Berlin (Verlag)
978-3-642-45160-7 (ISBN)

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Gene Network Inference -
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This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.

Simulation of the Benchmark Datasets.- A Panel of Learning Methods for the Reconstruction of Gene Regulatory Networks in a Systems Genetics Context.- Benchmarking a simple yet effective approach for inferring gene regulatory networks from systems genetics data.- Differential Equation based reverse-engineering algorithms: pros and cons.- Gene regulatory network inference from systems genetics data using tree-based methods.- Extending partially known networks.- Integration of genetic variation as external perturbation to reverse engineer regulatory networks from gene expression data.- Using Simulated Data to Evaluate Bayesian Network Approach for Integrating Diverse Data.

Erscheint lt. Verlag 15.1.2014
Zusatzinfo XI, 130 p. 49 illus., 33 illus. in color.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 385 g
Themenwelt Informatik Weitere Themen Bioinformatik
Naturwissenschaften Biologie Genetik / Molekularbiologie
Schlagworte gene expression • Gene Network Inference • gene networks • Network inference • systems biology • Systems Genetics
ISBN-10 3-642-45160-8 / 3642451608
ISBN-13 978-3-642-45160-7 / 9783642451607
Zustand Neuware
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