Protein Dynamics
Humana Press Inc. (Verlag)
978-1-62703-657-3 (ISBN)
In Protein Dynamics: Methods and Protocols, expert researchers in the field detail both experimental and computational methods to interrogate molecular level fluctuations. Chapters detail best-practice recipes covering both experimental and computational techniques, reflecting modern protein research. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Protein Dynamics: Methods and Protocols describes the most common and powerful methods used to characterize protein dynamics.
Monitoring Side-Chain Dynamics of Proteins Using 2H Relaxation.- CPMG Relaxation Dispersion.- Confocal Single-Molecule FRET for Protein Conformational Dynamics.- Protein Structural Dynamics Revealed by Site-directed Spin Labeling and Multifrequency EPR.- Probing Backbone Dynamics With Hydrogen/Deuterium Exchange Mass Spectrometry.- Carbon-Deuterium Bonds as Non-perturbative Infrared Probes of Protein Dynamics, Electrostatics, Heterogeneity, and Folding.- Balancing Bond, Nonbond and Gō-like Terms in Coarse Grain Simulations of Conformational Dynamics.- Tutorial on Building Markov State Models with MSMBuilder and Coarse-graining them with BACE.- Analysis of Protein Conformational Transitions Using Elastic Network Model.- Geometric Simulation of Flexible Motion in Proteins.- Principal Component Analysis: A Method for Determining the Essential Dynamics of Proteins.- A Case Study Comparing Quantitative Stability/Flexibility Relationships Across Five Metallo-β-Lactamases Highlighting Differences within NDM-1.- Towards Comprehensive Analysis of Protein Family Quantitative Stability/Flexibility Relationships using Homology Models.- Using the COREX/BEST Server to Model the Native State Ensemble.- Morphing Methods to Visualize Coarse-grained Protein Dynamics.
| Reihe/Serie | Methods in Molecular Biology ; 1084 |
|---|---|
| Zusatzinfo | 56 Illustrations, color; 26 Illustrations, black and white; XIV, 285 p. 82 illus., 56 illus. in color. |
| Verlagsort | Totowa, NJ |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Themenwelt | Informatik ► Weitere Themen ► Bioinformatik |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
| Schlagworte | coarse-grained techniques • dynamical timescales • molecular dynamics simulations • molecular level fluctuations • NMR techniques • Protein dynamics • spectroscopies |
| ISBN-10 | 1-62703-657-1 / 1627036571 |
| ISBN-13 | 978-1-62703-657-3 / 9781627036573 |
| Zustand | Neuware |
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