Systems Biology of Metabolic and Signaling Networks

Valdur Saks is Professor of Bioenergetics and Biochemistry at the University of Grenoble, France, and Head of the Laboratory of Bioenergetics at the National Institute of Chemical and Biological Physics in Tallinn, Estonia. A graduate of Moscow University, he was the long-time head of the Laboratory of Cardiac Bioenergetics in Moscow, Russia, before taking up his present positions. Professor Saks has authored over 220 scientific publications and has received numerous scientific awards, including the USSR State Prize in Science and the Internatinoal "Research and Development" Award sponsored by the U.N. and UNICEF. He is a member of the International Society for Heart Research and of the American Physiological and Biophysical Societies.

I Introduction.- From Physiology, Genomes, Systems and Self-Organization to Systems Biology: The Historical Roots of a 21st Century Approach to Complexity.- Systems Biology of Networks: The Riddle and the Challenge.- II Systems Biology of Signaling Networks.- Micrornas and Robustness In Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic And Genetic.- Dynamics of Mitochondrial Redox and Energy Networks: Insights from an Experimental-Computational Synergy.- Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling.- The Control Analysis of Signal Transduction.- III Systems Biology of Cellular Structures and Fluxes.- Moonlighting Function of the Tubulin Cytoskeleton.- Metabolic Dissipative Structures.- Systems Biology Approaches to Cancer Energy Metabolism.- IV Systems Biology of Organ Function.- Network Dynamics in Cardiac Electrophysiology.- Systems Level Regulation of Energy Fluxes via Metabolic Cycles. Role of Creatine and Phosphotransfer Pathways.- V Systems Biology of Microorganisms.- Temporal Partitioning of the Yeast Cellular Network.- Systems Biology and Metabolic Engineering in Bacteria.