Systems Biology in Cancer Research and Drug Discovery

Preface. I Systems Biology in Cancer.-1 Systems Biology Approach to Metabolomics in Cancer Studies.-2 System Biology Approach to Study Cancer Related Pathway.-3 Modeling Oncogenic Signaling Networks from Gene Expression Dynamics.-4 An Integrated Systems Approach to the Study of Pancreatic Cancer.-5 Protein Microarray: an Ideal Platform for Systems Biology.-6 Systems Biology of Pancreatic Cancer: the Role of Tumor-Microenvironment communication in Development, Progression and Therapy Resistance.II Systems Approaches to understand cancer Progression.-7 Understanding Cancer Progression Using Protein Interaction Networks.-8 Understanding the Dynamics of Tumor Angiogenesis: a Systems Biology Approach.-9 Applications of Network Bioinformatics to Cancer Angiogenesis.III Systems and Network Biology in decoding miRNA complexity.-10 Human MicroRNA Targetome Indicates a Specialized Role of MicroRNAs in Regulation of Oncogenesis.-11 Novel and Alternative Bioinformatics Approachesto understand miRNA-    mRNA Interactome in Cancer Research.-12 Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA-target Dysregulated  Network.IV Network Modeling in Cancer Drug Discovery and clinical trials.-13 Development and Clinical Implementation of Reverse Phase Protein Microarrays for Protein Network Activation Mapping: Personalized Cancer Therapy.-14 The Principle of Rational Design of Drug Combination and Personalized Therapy Based  on Network Pharmacology.-15 Relevance of Network Hierarchy in Cancer Drug-Target Selection.-16 Computational Infrastructures for Large Scale Data Access and Analysis in Post-Genomic Clinical Trials.-17 Network Pharmacology: an Emerging area in anti-cancer drug discovery.INDEX.