Controlled Release Veterinary Drug Delivery -

Controlled Release Veterinary Drug Delivery (eBook)

Biological and Pharmaceutical Considerations
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2000 | 1. Auflage
392 Seiten
Elsevier Science (Verlag)
978-0-08-052997-4 (ISBN)
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Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months).


The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field.


Controlled Release Veterinary Drug Delivery comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems.


The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.


Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months).The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field.Controlled Release Veterinary Drug Delivery comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems.The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.

Cover 1
Controlled Release Veterinary Drug Delivery: Biological and Pharmaceutical Considerations 4
Copyright Page 5
Contents 16
Foreword 8
Preface 10
Chapter 1. Utilization of biopharmaceutical and pharmacokinetic principles in the development of veterinary controlled release drug delivery systems 18
Chapter 2. Mechanisms of drug release from controlled release veterinary drug delivery systems 34
Chapter 3. Intraruminal controlled release products 68
Chapter 4. Design parameters for post-ruminal drug delivery systems and rumen-stable products 100
Chapter 5. Design and development of controlled release ocular veterinary drug delivery systems 132
Chapter 6. Design and development of controlled release intravaginal veterinary drug delivery systems 190
Chapter 7. Controlled release drug delivery systems for estrous control of domesticated livestock 218
Chapter 8. Controlled release products for control of ectoparasites of livestock 246
Chapter 9. Controlled release products for companion animals 266
Chapter 10. Controlled release vaccines in veterinary medicine 286
Chapter 11. In vitro drug release testing of controlled release veterinary drug products 328
Chapter 12. Stability testing of veterinary drug products 350
Chapter 13. USA regulatory aspects pertaining to controlled release veterinary drug delivery systems 370
Author Index 386
Subject Index 388

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