Fidelity and Quality Control in Gene Expression

Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. This book discusses processes such as aminoacylation of tRNAs and translation elongation itself. It focuses on: detection and elimination of defective mRNAs, recycling and translation re-initiation, and more.

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The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting.