Investigating the Human Genome
Financial Times Prentice Hall (Verlag)
978-0-13-216814-4 (ISBN)
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This book addresses into a wide spectrum of topics associated with human genetics and genomics, including:
Human origins; migrations and human population diversity gained though genomic analyses.
The complexities of psychiatric diseases that are influenced by genetics.
The pathogenesis of late-onset neurological diseases such as Alzheimer’s, Parkinsonism, and ALS.
Key aspects of protein misfolding.
Gene-environment interactions in DNA damage and repair and DNA instability.
Micro RNAs and mRNA translation.
Epigenetics.
New functions for old enzymes in cancer.
Moyra Smith is Professor of Pediatrics and Human Genetics at the School of Medicine at University of California, Irvine. A leading scholar in her field, she has served as an editor of McKusick’s classic “Red Book,” Mendelian Inheritance in Man. Smith’s monographs in the Oxford Series on Human Genetics include Mental Retardation and Developmental Delay: Genetic and Epigenetic Factors (2005), Translational Research in Genetics and Genomics (2008), and Phenotypic Variation: Exploration and Functional Genomics (2011).
Preface vii
Chapter 1 Genome Architecture and Sequence Variation in Health and Disease 1
Chapter 2 Genes and Transcripts: Insight into Regulation at Different Levels 23
Chapter 3 Epigenetics: Modifications of DNA, Chromatin, and Gene Expression 37
Chapter 4 Gene Environment Interactions 53
Chapter 5 Pathways, Phenotypes, and Phenocopies 67
Chapter 6 Dynamic Function, Synaptic Activity, and Plasticity 81
Chapter 7 Late Onset Neurodegenerative Diseases 101
Chapter 8 Genes and Genomes in Cancer: Targeted Therapies 131
Chapter 9 Functional Genomics: Personalized Medicine and Therapeutics 153
Epilogue 167
References 171
About the Author 203
Index 205
| Erscheint lt. Verlag | 14.7.2011 |
|---|---|
| Zusatzinfo | Illustrations |
| Verlagsort | Upper Saddle River |
| Sprache | englisch |
| Maße | 191 x 237 mm |
| Gewicht | 400 g |
| Themenwelt | Schulbuch / Wörterbuch |
| Informatik ► Weitere Themen ► Bioinformatik | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Sozialwissenschaften ► Pädagogik | |
| ISBN-10 | 0-13-216814-6 / 0132168146 |
| ISBN-13 | 978-0-13-216814-4 / 9780132168144 |
| Zustand | Neuware |
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