An Introduction to Adaptive Designs with Applications to Clinical Trials Using R

* Practical examples are illustrated throughout the book * Plentiful exercises are presented to further reinforce the concepts discussed. * Research in frontier studies and analyses is laid-out in such a way as to seem accessible and understandable. * The R language is employed throughout.

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This book presents an up-to-date, accessible, and authoritative look into the rapidly emerging study of statistical adaptive design. Employing the R language throughout, it emphasizes the usefulness of adaptive design methods and technology in public health and research settings through practical examples and plentiful exercises. Special focus is on adaptive late-stage clinical trial designs as extensions of the highly successful group sequential methods that have been applied for more than two decades. It is the first elementary text on the subject matter that is aimed at clinicians, investigators, credit rating analysts, medical writers, regulatory affairs specialists, and applied statisticians.