Microsatellites - David B. Goldstein

Microsatellites

Buch | Hardcover
240 Seiten
1999
Oxford University Press (Verlag)
978-0-19-850408-5 (ISBN)
68,55 inkl. MwSt
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Provides a description of microsatellite biology, focusing on mutation properties, generation, decay, and possible functional roles. The text introduces theoretical models that underpin methods for analyzing the information that microsatellites can yield, including methods for estimating migration.
Microsatellites are short stretches of repeated DNA, found in most genomes, that show exceptional variability in humans and most other species. This variability has made microsatellites the genetic marker of choice for most applications, including genetic mapping and studies of the evolutionary connections between species and populations. This book brings together an international group of scientists working in microsatellites. Their contributions provide a description of microsatellite biology, focusing on their mutation properties, generation, decay, and possible functional roles. They introduce the theoretical models that underpin the most popular methods for analyzing the information that microsatellites can yield, including methods for estimating coalescent times, population divergences and migration. Finally, the book describes the various ways in which the potential of microsatellites is being harnessed in a range of applications including medical genetics, forensics, genetic mapping, the analysis of human evolution and conservation genetics.
This book is intended for graduate students and researchers in evolutionary biology and anyone using or considering the use of genetic markers - researchers in ecology, evolution, anthropology, medical genetics, molecular biology, behaviour and forensic science.

1: Hancock: Microsatellites and other simple sequences; 2: Kashi and Soller: Functional roles of microsatellites and minisatellites; 3: Armour et al: Microsatellites and mutation processes in tandemly repetitive DNA; 4: Eisen: Mechanistic basis for microsatellite instability; 5: Estoup and Cornuet: Microsatellite evolution: inferences from population data; 6: Amos: A comparative approach to the study of microsatellite evolution; 7: Rubinsztein: Trinucleotide expansion mutations cause diseases which do not conform to Mendelian expectations; 8: Feldman: Mutation and migration in models of microsatellite evolution; 9: Donnelly: The coalescent and microsatellite variability; 10: Reich and Goldstein: Estimating the age of mutations using variation of linked markers; 11: Chakraborty and Kimmel: Statistics of microsatellite loci: Estimation of mutation rate and pattern of population expansion; 12: Pemberton et al: Using microsatellites to measure the fitness consequences of inbreeding and outbreeding; 13: Beaumont and Bruford: Microsatellites in conservation genetics; 14: Linares: Microsatellites and the reconstruction of the history of human populations; 15: Balding: Forensic applications of microsatellite markers; 16: Stephens et al: Tracking linkage disequilibrium in advanced population with microsatellite loci; 17: Carrington et al: Microsatellite markers in complex disease: mapping disease - associated regions within the human MHC; 18: Schlotterer and Wiehe: Microsatellites: a neutral marker to infer selective sweeps; 19: Karafet et al: Y chromosome microsatellite haplotypes and the history of Samoyed-speaking populations in N-W Siberia; 20: Shibata: MS analysis of human tumours.

Co-Autor Christian Schlotterer
Zusatzinfo Illustrations
Verlagsort Oxford
Sprache englisch
Themenwelt Informatik Weitere Themen Bioinformatik
Naturwissenschaften Biologie Evolution
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
Sozialwissenschaften Soziologie
ISBN-10 0-19-850408-X / 019850408X
ISBN-13 978-0-19-850408-5 / 9780198504085
Zustand Neuware
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