Microsatellites: Evolution and Applications

David B Goldstein, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS david.goldstein@zoo.ox.ac.uk Christian Schlötterer, Institut für Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Vienna, Austria christian.schloetterer@vu-wien.ac.at

1. Microsatellites and other simple sequences ; 2. Functional roles of microsatellites and minisatellites ; 3. Microsatellites and mutation processes in tandemly repetitive DNA ; 4. Mechanistic basis for microsatellite instability ; 5. Microsatellite evolution : inferences from population data ; 6. A comparative approach to the study of microsatellite evolution ; 7. Trinucleotide expansion mutations cause diseases which do not conform to Mendelian expectations ; 8. Mutation and migration in models of microsatellite evolution ; 9. The coalescent and microsatellite variability ; 10. Estimating the age of mutations using variation of linked markers ; 11. Statistics of microsatellite loci : Estimation of mutation rate and pattern of population expansion ; 12. Using microsatellites to measure the fitness consequences of inbreeding and outbreeding ; 13. Microsatellites in conservation genetics ; 14. Microsatellites and the reconstruction of the history of human populations ; 15. Forensic applications of microsatellite markers ; 16. Tracking linkage disequilibrium in advanced population with microsatellite loci ; 17. Microsatellite markers in complex disease : mapping disease - associated regions within the human MHC ; 18. Microsatellites : a neutral marker to infer selective sweeps ; 19. Y chromosome microsatellite haplotypes and the history of Samoyed-speaking populations in N-W Siberia ; 20. MS analysis of human tumours