Regulation of microRNAs

Helge Großhans, PhD is a research group leader at the Friedrich Miescher Institute for Biomedical Research (FMI), which is part of the Novartis Research Foundation in Basel, Switzerland. His main research interests are in the developmental function, regulation, and mechanism of action of microRNAs. He received his PhD from the University of Heidelberg and did his postdoctoral training at Yale University. He is the winner of a 2009 ERC Award.

microRNA Biogenesis and Function.- Regulation of pri-miRNA Processing Through Smads.- Stimulation of pri-miR-18a Processing by hnRNP A1.- KSRP Promotes the Maturation of a Group of miRNA Precuresors.- Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor.- Autoregulatory Mechanisms Controlling the Microprocessor.- Regulation of pre-miRNA Processing.- The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function.- miRNAs Need a Trim.- Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression.- Turnover of Mature miRNAs and siRNAs in Plants and Algae.- MicroRNases and the Regulated Degradation of Mature Animal miRNAs.