Principles of Toxicology – Environmental and Industrial Applications 3e

Stephen M. Roberts, PhD, is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville Robert C. James, PhD, is Senior Principal Scientisst, ToxStrategies, Inc., Tallahassee, Florida, and Associate Scientist at the Center for Environmental and Human Toxicology at the University of Florida, Gainesville Phillip L. Williams, PhD, is Dean & Georgia Power Professor at the University of Georgia, Athens

Contributors vii Preface ix 1 General Principles of Toxicology 1 Robert C. James, Stephen M. Roberts, and Phillip L. Williams 2 Xenobiotic Absorption, Distribution, Metabolism, and Excretion 29 Michael R. Franklin 3 Toxicokinetics 59 Rebecca A. Clewell and Harvey J. Clewell III 4 Omics Technologies in Toxicology 89 Mary Jane Cunningham 5 Toxicity of the Hematopoietic System 103 Sherilyn A. Gross 6 Hepatotoxicity: Toxic Effects on the Liver 125 Robert C. James and Stephen M. Roberts 7 Nephrotoxicity: Toxic Responses of the Kidney 139 Lawrence H. Lash 8 Neurotoxicity: Toxic Effects on the Nervous System 157 William M. Caudle and Gary W. Miller 9 Dermatotoxicity: Toxic Effects on the Skin 169 Sailesh Konda and Howard I. Maibach 10 Pulmonotoxicity: Toxic Effects in the Lung 179 Cuiqing Liu and Qinghua Sun 11 Immunotoxicity: Toxic Effects on the Immune System 197 Eric S. Sobel and Stephen M. Roberts 12 Toxic Effects on Reproduction 211 Mary L. Hixon 13 Developmental Toxicology 223 Vincent F. Garry and Peter L. Truran 14 Mutagenesis and Genetic Toxicology 235 Martha M. Moore, Meagan B. Myers, and Robert H. Heflich 15 Chemical Carcinogenesis 259 James E. Klaunig 16 Properties and Effects of Metals 283 David B. Mayfield, Ari S. Lewis, Lisa A. Bailey, and Barbara D. Beck 17 Properties and Effects of Pesticides 309 Janice Britt 18 Properties and Effects of Solvents and Solvent-Like Chemicals 325 Christopher M. Teaf, Michele M. Garber, and J. Michael Kuperberg 19 Nanotoxicology 359 Hongbo Ma, Steve Diamond, Georgia Hinkley, and Stephen M. Roberts 20 Computational Toxicology 373 Richard S. Judson, David M. Reif, and Keith A. Houck 21 E pidemiological Issues in Occupational and Environmental Health 391 Michael S. Bloom and John E. Vena 22 Occupational and Environmental Health 411 Brenda S. Buikema, T. Renee Anthony, and Fredric Gerr 23 Human Health Risk Assessment 425 Leah D. Stuchal, Robert C. James, and Stephen M. Roberts Glossary 457 Index 471