From Basic Pain Mechanisms to Headache

SECTION I - MOLECULAR MECHANISMS IN INFLAMMATORY PAIN ; 1. Somatostatin and calcitonin gene-related peptide (CGRP) receptors in primary afferent neurons ; 2. The capsaicin receptor controls sensitivity and stimulated neuropeptide release in rodent meninges ; 3. Cytokines in inflammatory pain ; 4. Discussion summary: Molecular mechanisms in inflammatory pain ; SECTION II - NEUROBIOLOGY OF NEUROPATHIC PAIN ; 5. Mechanisms of inflammatory hyperalgesia ; 6. Translation of symptoms and signs into mechanisms in neuropathic pain ; 7. Neuropathic pain in the orofacial area ; 8. Discussion summary: Neurobiology of neuropathic pain ; SECTION III - THE TRIGEMINAL SYSTEM AND PAIN ; 9. Injury induced neuroplastic changes in trigeminal brainstem subnucleus caudalis: Trigeminal central sensitisation ; 10. Vascular and neuronal mechanisms related to the trigeminovascular system ; 11. Pathophysiological considerations in trigeminal neuralgia ; 12. Parasympathetic activation in experimental trigeminal pain ; 13. Trigeminovascular activation in cervicogenic headache ; 14. Hypertension-associated hypalgesia: an important mechanism in headache and other pains? ; 15. Central projections of sensory innervation of the rat superior sagittal sinus ; 16. Discussion summary: the trigeminal system and pain ; SECTION IV - ALLODYNIA AND HYPERALGESIA ; 17. Mechanisms of cutaneous hyperalgesia ; 18. Allodynia as a manifestation of migraine and other headaches ; 19. Muscular hyperalgesia in the head and orofacial area ; 20. Evidence for generalized muscular and cutaneous hyperalgesia in patients with chronic tension-type headache ; 21. Migrainous allodynia or triptan-induced allodynia? ; 22. Migraine facilitates high frequency of tension-type headache ; 23. Clinical assessment of hyperalgesia and allodynia in episodic migraine versus chronic migraine interictally and ictally ; 24. Discussion summary: Allodynia and hyperalgesia ; SECTION V - MODULATION OF PAIN ; 25. Mechanisms of pain facilitation systems: implications for medication overuse headache ; 26. Brainstem mechanisms of ongoing pain ; 27. How the brain talks to the spinal cord ; 28. Eletriptan in migraine: is pain-free response correlated with pain severity or time from headache onset to dosing? ; 29. Efficacy of eletriptan in improving functional impairment in migraine: results using a multidimensional functional and work productivity battery ; 30. CNS adverse events in patients treated with triptans: side effect or symptom? ; 31. Discussion summary: Modulation of pain ; SECTION VI - IMAGING OF PAIN AND ALLODYNIA ; 32. Cognitive control of emotion and pain in the human brain ; 33. Brain imaging of allodynia and hyperalgesia ; 34. Functional neuroimaging of primary headaches ; 35. Posterior cerebral hypoperfusion in migraine without aura ; 36. Brainstem and hypothalamic activation in spontaneous migraine attacks: a PET study ; 37. Discussion summary: Imaging of pain and allodynia