Autosomal Dominant Alzheimer's Disease

Jasmeer Chhatwal MD PhD MMSc, Assistant Professor of Neurology, Harvard Medical School; Associate Neurologist, Massachusetts General Hospital. Dr. Chhatwal is a neurologist and translational neuroscientist at Harvard Medical School who uses a diverse array of genetic, neuroimaging, and biochemical tools to study Alzheimer’s disease. He serves as a site leader for the Dominantly Inherited Alzheimer’s Network (DIAN), a project leader for the Harvard Aging Brain Study, and leads studies examining potentially modifiable risk factors for cognitive decline in older adults. Clinically, he sees a wide variety of patients with cognitive disorders, with a particular focus on early onset Alzheimer's disease (AD). Eric McDade, DO, Associate Professor of Neurology, Washington University School of Medicine at St. Louis. Dr. McDade is a Neurologist with a specialty in Cognitive Neurology. He is the Associate Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) and the Clinical Core lead of the Dominantly Inherited Alzheimer Network. Dr. McDade’s clinical research focuses on fluid and imaging biomarkers in preclinical Alzheimer disease and their application in the development of Alzheimer prevention clinical trials. He leads the DIAN-TU Primary Prevention Trial.

1. Introduction 2. History of ADAD 3. Cognitive Trajectories in ADAD 4. Beyond Memory Loss: Non-Amnestic Manifestations of ADAD 5. Towards a Unified Framework in Sporadic and Genetically driven AD: Neuroimaging and Biomarker Trajectories in ADAD 6. Applying lessons from ADAD to sporadic AD 7. Mechanisms underlying ADAD mutations 8. Heterogeneity Across ADAD Genotypes 9. Lessons from AD in Down's Syndrome 10. Neuropathology of ADAD 11. ADAD Experimental Therapeutics