Assessing Quality of Life in Clinical Trials
Oxford University Press (Verlag)
978-0-19-852769-5 (ISBN)
Quality of Life Assessment has progressed considerably since the publication of the first highly acclaimed edition of this book in 1998. Quality of life has now become an indispensable outcome measure in many randomised clinical trials and other studies. Thus, it is timely to provide not just an update, but a completely new edition that reviews the current state of art and also discusses topical issues including areas where active research is in progress.
The first section discusses the development and evaluation of generic and disease-targeted questionnaires. Having decided the items to be included the thrust of the next section covers how to convert these into usable forms. Section 3 addressing analysis and the methods of analysing studies with missing data is followed by chapters on interpretation of results and exploring the role of single-item questions. The final section of the book looks beyond the individual clinical trial and how we can use clinical trial and other data to make macro-decisions.
A strong international team of experts cover a wide range of topics, emphasizing new and innovative approaches that are of practical and clinical importance, reviewing the current state of the art and illustrating the benefits and potential of health related quality of life assessment in clinical trials.
Preface ; 1. DEVELOPING AND EVALUATING QUESTIONNAIRES ; 1.1 Generic versus disease-targeted instruments ; 1.2 Developing questionnaires ; 1.3 Reliability and validity, including responsiveness ; 1.4 Evaluating multi-item scales ; 1.5 Rasch models & IRT ; 2. ADAPTING AND USING QUESTIONNAIRES ; 2.1 Translating and evaluating questionnaires - cultural issues ; 2.2 CAT and item banking ; 2.3 Developing a questionnaire using IRT - a case study of fatigue ; 2.4 Proxy assessments and context effects ; 3. ANALYSIS ; 3.1 Analysing longitudinal studies of QOL ; 3.2 Preventing missing data ; 3.3 Analysing studies with missing data ; 3.4 Differential item functioning (DIF) for analysing cultural differences ; 3.5 Reporting analyses from clinical trials ; 4. INTERPRETING QOL IN INDIVIDUALS AND GROUPS ; 4.1 Individualised QoL ; 4.2 Meaningful differences ; 4.3 Health-related QoL outcomes in clinical trials ; 4.4 Response shift ; 4.5 Individual patient monitoring ; 5. MEASURES FOR CLINICAL TRIALS ; 5.1 Self-rated health ; 5.2 Generic adult health status measures ; 5.3 Measurement of HRQL in child/adolescent clinical trials ; 5.4 Developing disease-targeted measures for neurolgic conditions ; 6. BEYOND CLINICAL TRIALS ; 6.1 Values and valuation ; 6.2 Preference-based measures ; 6.3 Discrete choice experiments ; 6.4 Combining clinical trials - meta analysis
| Erscheint lt. Verlag | 10.3.2005 |
|---|---|
| Zusatzinfo | numerous tables |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 175 x 248 mm |
| Gewicht | 931 g |
| Themenwelt | Geisteswissenschaften ► Psychologie ► Klinische Psychologie |
| Medizin / Pharmazie ► Gesundheitswesen | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
| ISBN-10 | 0-19-852769-1 / 0198527691 |
| ISBN-13 | 978-0-19-852769-5 / 9780198527695 |
| Zustand | Neuware |
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