Collagenase in Dupuytren Disease

Dr. Giorgio Eugenio Pajardi is Professor of Plastic and Reconstructive Surgery at Università degli Studi di Milano, Milan, Italy, where he is director of various courses on hand surgery and rehabilitation. While hand surgery is his principal field of interest, he is also a specialist in peripheral nerve surgery, neuro-orthopedic surgery, and reconstructive microsurgery. His mentors were in Italy Professor Ezio Morelli and outside Professor Guy Foucher, and Professor Pajardi adheres to the French School's emphasis on hand surgery and hand rehabilitation as synergistic pillars of treatment. Professor Pajardi is the author of approximately 170 national and international publications and is a regular lecturer at national and international congresses. He is a member of the Italian Society of Plastic and Reconstructive Surgery, the Italian Society of Hand Surgery, and the International Federation of Hand Surgery Societies. He is also President of Centro Studi Mano, a cultural not for profit foundation whose statutory goal is to promote teaching and improve career pathways for young students. Dr. Marie Badalamente is Professor of Orthopaedics at Stony Brook University Medical Center, Stony Brook, New York, USA. She is the author of over 68 publications and 150 abstract/presentations. Along with Dr. Hurst, she is the inventor of collagenase clostridium histolyticum (CCH) in the treatment of Dupuytren disease through the Food and Drug Administration clinical trials process in the USA. As CCH is potentially a multi-use drug, Dr. Badalamente continues her research in it's use for other medical indications, such as, adhesive capsulitis (frozen shoulder). Dr. Badalamente is a member of the American Society for Surgery of the Hand, American Acadmeny of Orthopaedic Surgeons and the Orthopaedic Research Society. Dr. Lawrence C. Hurst is Professor and Chairman of the Department of Orthopaedics, Chief of Hand Surgery, and Director of the Hand Fellowship Training Program at Stony Brook University Medical Center and CEO & Editor at Hand Surgery Resource, LLC. Dr. Hurst is an active member of various professional societies, including the American Society for Surgery of the hand, the American Orthopaedic Association, the American Academy of Orthopaedic Surgeons, the Robert E. Carroll Hand Club, and the New York Society for Surgery of the Hand. Dr. Hurst's research interests include the safe and efficacious use of collagenase treatment in Dupuytren's disease. He is widely published in peer-reviewed journals, such as Hand Surgery, Journal of Hand Surgery and the New England Journal of Medicine. He has authored numerous book chapters, including the chapter on Dupuytren's disease in the 6th edition of Green's Operative Hand Surgery. He is Editor & Principle Author of www.handsurgeryprimer.org, a web-based hand surgery teaching tool. Dr. Hurst earned his medical degree at the University of Vermont College of Medicine and completed his residency in orthopaedic surgery at the University of North Carolina at Chapel Hill. He completed a fellowship in hand surgery at Columbia Presbyterian Medical Center and is board-certified by the American Board of Orthopaedic Surgery with a Certificate of Added Qualifications in Surgery of the Hand.

1 Biochemistry and mechanism of action of collagen.- 2 Pre-Clinical evaluation and early clinical trials in USA.- 3 Dupuytren's Disease: topographic anatomy of lesions.- 4 Experimental phase in Europe: protocol and first results.- 5 Preparation, injection and traction procedures (Pearls and Tips & Tricks): technical evolution.- 6 First web space, thumb, and nodules.- 7 Rehabilitation after treatment.- 8 Collagenase today: follow-up studies, recurrence, dosage, drug safety.- 9 American and European Regulations.- 10 Collagenase: future perspectives.