Collagenase in Dupuytren Disease

Giorgio Eugenio Pajardi is Professor of Plastic and Reconstructive Surgery at Università degli Studi di Milano, Milan, Italy, where he is director of various courses on hand surgery and rehabilitation. While hand surgery is his principal field of interest, he is also a specialist in peripheral nerve surgery, neuro-orthopedic surgery, and reconstructive microsurgery. His mentor was Professor Guy Foucher, and Professor Pajardi adheres to the French School’s emphasis on hand surgery and hand rehabilitation as synergistic pillars of treatment. Professor Pajardi is the author of approximately 170 national and international publications and is a regular lecturer at national and international congresses. He is a member of the Italian Society of Plastic and Reconstructive Surgery, the Italian Society of Hand Surgery, and the International Federation of Hand Surgery Societies. He is also President of Centro Studi Mano, a cultural not for profit foundation whose statutory goal is to promote teaching and improve career pathways for young students. 

1 Biochemistry and mechanism of action of collagen.- 2 Pre-Clinical evaluation and early clinical trials in USA.- 3 Dupuytren's Disease: topographic anatomy of lesions.- 4 Experimental phase in Europe: protocol and first results.- 5 Preparation, injection and traction procedures (Pearls and Tips & Tricks): technical evolution.- 6 First web space, thumb, and nodules.- 7 Rehabilitation after treatment.- 8 Collagenase today: follow-up studies, recurrence, dosage, drug safety.- 9 American and European Regulations.- 10 Collagenase: future perspectives.