The Perioperative Neurocognitive Disorders

Roderic G. Eckenhoff is an anesthesiologist and scientist at the University of Pennsylvania Perelman School of Medicine. He holds the Austin Lamont Chair in Anesthesiology and Critical Care and is Vice Chair for Research in that department. His primary research interest has been in the molecular pharmacology of general anesthetics, work that revealed effects on protein structure and function that should translate to neurodegenerative diseases and neuroinflammation. Niccolò Terrando is a neuroscientist at Duke University, North Carolina. His laboratory studies the pathogenesis of perioperative neurocognitive disorders, with emphasis on the mechanisms whereby surgery affects brain function and how regulation of neuro-immune processes can be targeted to develop safer mitigation strategies to prevent these common postoperative complications.

Part I. Cognitive Function in Perioperative Care: 1. Emergence delirium: a new hypothesis for an old problem Alexander Proekt; 2. Postoperative delirium Jennifer Gabbard, Frederick E. Sieber and Esther S. Oh; 3. Postoperative cognitive dysfunction: an overview Jennifer Nelli, Deborah J. Culley and Gregory Crosby; 4. Postoperative cognitive improvement Franchesca Arias, Kimberly T. Sibille and Catherine C. Price; 5. Persistent perioperative neurocognitive disorder: does surgery accelerate dementia? Katie J. Schenning and Kirk J. Hogan; Part II. Pathophysiology of the Perioperative Neurocognitive Disorders: 6. Animal models and cognitive testing of perioperative neurocognitive disorder Maryellen F. Eckenhoff and Colm Cunningham; 7. Anesthesia and neurodegeneration Phillip Vlisides and Zhongcong Xie; 8. Pharmacologic (receptor-based) mechanisms of postoperative cognitive dysfunction Lauren G. Powlovich and Zhiyi Zuo; 9. Surgery and the inflammatory response Azeem Alam and Daqing Ma; 10. Comorbidities and prolonged cognitive decline Mervyn Maze and Xiaomei Feng; Part III. Symptomatology and Diagnosis for the Perioperative Neurocognitive Disorders: 11. Cognitive testing for perioperative neurocognitive disorder Lisbeth Evered; 12. Biomarkers of postoperative cognitive dysfunction: finding the signal amidst the noise Miles Berger, S. Kendall Smith and Anver Khan; 13. Neuroimaging in the perioperative neurocognitive disorders James W. Ibinson; Part IV. Clinical Recommendations and Prevention: 14. Preoperative testing to identify vulnerable subgroups Deborah J. Culley; 15. Informed consent and cognitive impairment Brendan Silbert and David A. Scott; 16. Perioperative neurocognitive disorder mitigation strategies Roderic G. Eckenhoff and Niccolò Terrando.