Neuroscience of Nicotine

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

1. Understanding Tobacco Use in Different Countries 2. Maternal Smoking and Fetal Brain Outcome: Mechanisms and Possible Solutions 3. Nicotine Effects in Adolescents 4. The Impact of Traditional Cigarettes and ECigarettes on the Brain 5. Reduction of Nicotine in Tobacco and Impact 6. Prenatal Nicotine Exposure and Neuronal Progenitor Cells 7. Synaptically Located Nicotinic Acetylcholine Receptor Subunits in Neurons Involved in Dependency to Nicotine 8. Cotinine as a Possible Allosteric Modulator of Nicotine Effects in Various Models 9. Nicotine, Neural Plasticity, and Nicotine’s Therapeutic Potential 10. Habenular Synapses and Nicotine 11. Nicotine Neuroprotection of Brain Neurons: The Other Side of Nicotine Addiction 12. Linking Nicotine, Menthol, and Brain Changes 13. Cigarette Smoking and Nicotine: Effects on Multiple Sclerosis 14. Tobacco and Positron-Emission Tomography (PET) of the Dopaminergic System: A Review of Human Studies 15. Resting-State Functional Connectivity Imaging and Nicotine Dependence 16. Functional Magnetic Resonance Imaging of Acute Nicotine Effects 17. Nicotine Dependence in Schizophrenia: Contributions of Nicotinic Acetylcholine Receptors 18. Attentional Bias and Smoking 19. Effects of Nicotine on Inhibitory Control in Humans 20. Nicotine, Corticotropin-Releasing Factor, and Anxiety-Like Behavior 21. 6-Hydroxy-L-Nicotine and Memory Impairment 22. Cotinine and Memory: Remembering to Forget 23. Nicotine in Aberrant Learning and Corticostriatal Plasticity 24. Prenatal Nicotine Exposure and Impact on the Behaviors of Offspring 25. Craving in Substance Use Disorders With a Focus on Cigarette Smoking 26. The Acute Effect of Exercise on Cravings and Withdrawal Symptoms 27. CRF2 Receptor Agonists and Nicotine Withdrawal 28. Delirium and Nicotine Withdrawal 29. Postoperative Nicotine Withdrawal 30. Nicotine and Alpha3beta2 Neuronal Nicotinic Acetylcholine Receptors 31. Nicotine Addiction and Alpha4beta2* Nicotinic Acetylcholine Receptors 32. The Medial Habenula-Interpeduncular Nucleus Pathway in Nicotine Sensitization: The Role of a3ß4 Nicotinic Acetylcholine Receptors and Substance P 33. Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain 34. Pharmacology of Muscle-Type Nicotinic Receptors 35. Involvement of Opioid Receptors in Nicotine-Related Reinforcement and Pleasure 36. Nicotine-Induced Kindling: Influences of Age, Sex, and Prevention by Antioxidants 37. Nicotine Reward and Abstinence: Role of the CB1 Receptors 38. The Therapeutic Potential of the Cognitive- Enhancing Effects of Nicotine and Other Nicotinic Acetylcholine Receptor Agonists 39. Nicotine and Dopamine DA1 Receptor Pharmacology 40. Brain Gene Expression in the Context of Nicotine Rewards: A Focus on Cholinergic Genes 41. HIV-Infected Subjects and Tobacco Smoking: A Focus on Nicotine Effects in the Brain 42. Renin-Angiotensin System Genes and Nicotine Dependence 43. Nicotine Dependence and the CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome 44. Brain, Nrf2, and Tobacco: Mechanisms and Countermechanisms Underlying Oxidative-Stress-Mediated Cerebrovascular Effects of Cigarette Smoking 45. Effects of Nicotine and Histone Deacetylase Inhibitors on the Brain 46. L-Type Calcium Channels and Nicotine 47. The Co-occurrence of Nicotine With Other Substance Use and Addiction: Risks, Mechanisms, onsequences, and Implications for Practice,With a Focus on Youth 48. Comorbid Smoking and Gambling Disorder: Potential Underlying Mechanisms and Future Explorations 49. Neuroscience of Tobacco and Crack Cocaine Use: Metabolism, Effects, and Symptomatology 50. Salivary Cotinine Assays 51. Overview of Cotinine Cutoff Values for Smoking Status Classification 52. Smoking Abstinence Expectancies Questionnaire 53. Pharmacist-led Smoking Cessation Services: Current and Future Perspectives 54. Nicotine Use and Weight Control in Young People: Implications for Prevention and Early Intervention 55. Exercise as a Smoking Cessation Aid 56. Varenicline: Treating Smoking Addiction and Schizophrenia 57. Nicotine Vaccines: The Past, the Present, and the Future 58. Treating Nicotine Dependence in Psychiatric Hospitals 59. Oral 18-Methoxycoronaridine (18-MC) Decreases Nicotine Self-Administration in Rats 60. Pharmacogenetics and Smoking Cessation 61. The Orexin System and Nicotine Addiction: Preclinical Insights 62. Tobacco Control Policies and Smokers’ Responses 63. Resources for the Neuroscience of Nicotine