Negative Affective States and Cognitive Impairments in Nicotine Dependence

Dr. F. Scott Hall is an Assistant Professor of Pharmacology and Experimental Therapeutics in the College of Pharmacy and Pharmaceutical Sciences at the University of Toledo. Dr. Hall’s research investigates the genetic and environmental determinants of susceptibility to addiction and related psychiatric disorders. After a B.A. from Harvard University (1987) and a Ph.D. from the University of Cambridge in 1994, Dr. Hall completed a postdoctoral fellowship at the National Institute on Alcoholism and Alcohol Abuse. Dr. Hall joined the Molecular Neurobiology Branch at the National Institute on Drug Abuse in 1999 where he led the behavioral genetics group until 2014. He has authored over a hundred scientific publications and is a fellow of the International Behavioral Neuroscience Society. Dr. Hall is recognized internationally as an expert in the genetic basis of addiction and the role that early social experience plays in shaping adult behavior and behavioral pathology. I am a Scottish Neuropsychopharmacologist in Sunny California, Dept. of Psychiatry, UCSD. My primary interest is investigating the neural mechanisms underlying cognitive dysfunction in order to develop targeted therapeutics. I specialize in cross-species testing and as such have developed/aided in the development of many such tests including the 5-choice continuous performance test, now in use across the globe, in patients, rats, and mice, with fMRI and EEG recording also available. With regards to clinical populations, I have investigated diseases such as schizophrenia, bipolar disorder, HIV, Tourette’s syndrome, as well as methamphetamine, nicotine, and cannabis abuse. Using this cross-species behavioral testing approach, any work we conduct we hope will have relevance to clinical populations and vice-versa. With this dual approach combined with networking with great collaborators, I hope that more promising therapeutics will not be far away. Andre Der-Avakian, Ph.D., is an Assistant Research Scientist in the Department of Psychiatry at University of California, San Diego and an Adjunct Instructor in the Department of Psychological Sciences at University of San Diego. He received his Ph.D. in Neuroscience from University of Colorado, Boulder and completed a National Institute of Mental Health-sponsored postdoctoral fellowship at University of California, San Diego. Dr. Der-Avakian has published several research articles, reviews, and book chapters on the neurobiology of stress-induced disruption of normal reward processing in rats that may contribute to symptoms like anhedonia and motivational deficits in psychiatric disorders. His research, which is funded by grants from the National Institute of Mental Health and the National Institute on Drug Abuse, is focused on designing and implementing new translational behavioral and neurophysiological assessments of reward and cognitive processes in rats with high relevance to human psychiatric disorders like depression, schizophrenia, and drug addiction.

1. Overview of Nicotine Withdrawal and Negative Reinforcement (Preclinical). Olivier George and George F. Koob. 2. Nicotine withdrawal and attentional deficit studies across species: Conflation with attentional dysfunction in psychiatric patients. Jordy van Enkhuizen and Jared W. Young. 3. Preclinical models of nicotine withdrawal: targeting impaired cognition. Mohammed Shoaib and F. Scott Hall. 4. Genetic, developmental, and receptor level influences on nicotine withdrawal-associated deficits in learning. Munir G. Kutlu, Erica Holliday and Thomas J. Gould. 5. Enhanced tobacco use vulnerability in adolescents, females and persons with diabetes. Joseph A Pipkin, Tiahna Ontiveros and Laura E. O’Dell. 6. Detrimental effects of prenatal exposure to tobacco smoke and nicotine. Tomasz Schneider. 7. Contribution of mouse genetic models to our understanding of nicotine dependence. F. Scott Hall, Yosefu Arime, Yasir Saber and Ichiro Sora. 8. Transmitters and receptors in nicotine withdrawal syndrome. David H. Malin, Andrea N. Anderson and Pilar Goyarzu. 9. The cannabinoid system in nicotine dependence and withdrawal. Meghan E. Mcilwain, Arpi Minassian, and William Perry. 10. Critical role for brain stress systems in the negative affective state associated with nicotine withdrawal. Xiaoli Zi, Dawn M. Bruijnzeel, and Adriaan W. Bruijnzeel. 11. The habenula-interpeduncular pathway and nicotine withdrawal. Christie D. Fowler. 12. A Clinical overview of nicotine dependence and withdrawal. Mai Frandsen, Mona Thorpe, Saul Shiffman, and Stuart G. Ferguson. 13. Epidemiologic research on the relationship of nicotine dependence to psychiatric and substance use disorders. Kate S. Segal, Hannah Esan, Alyssa R. Burns, and Andrea H. Weinberger. 14. Nicotine and tobacco smoking and withdrawal in schizophrenia. Karolina Kozak and Tony P. George. 15. Emergent cognitive impairment during early nicotine withdrawal. Randi M. Schuster and A. Eden Evins. 16. Nicotine and posttraumatic Stress Disorder. Dean T. Acheson and Daniel E. Glenn. 17. Nicotine withdrawal and depression: Clinical studies – a four-factor model for more accurate characterization. David G. Gilbert and Michel L. Pergadia. 18. Neuroimaging insights into the multifaceted nature of the nicotine withdrawal syndrome. Matthew T. Sutherland, Julio A. Yanes, and Elliot A. Stein.