The Cell. International Edition

Geoffrey M. Cooper is Professor of Biology and Associate Dean of the Faculty for Natural Sciences at Boston University. Receiving a Ph.D. in Biochemistry from the University of Miami in 1973, he pursued postdoctoral work with Howard Temin at the University of Wisconsin, where he developed gene transfer assays to characterize the proviral DNAs of Rous sarcoma virus and related retroviruses. He then joined the faculty of Dana-Farber Cancer Institute and Harvard Medical School in 1975, extending these studies to the identification of oncogenes in human tumors. Since moving to Boston University as Chair of Biology in 1998, Dr. Cooper has used The Cell in teaching undergraduate cell biology, as well as continuing his research and participating in a major expansion of the life sciences there. Dr. Cooper's research is focused on understanding the roles of oncogene proteins in the signaling pathways that regulate cell proliferation and programmed cell death. He has authored two textbooks on cancer and published over 100 research papers in the field of cell signaling and cancer research.

Part I. Fundamentals and Foundations1. An Overview of Cells and Cell ResearchNew discussion of super-resolution light microscopyNew Key Experiment: HeLa cells2. Molecules and MembranesReorganized to include discussion of enzymes and catalysis3. Bioenergetics and MetabolismReorganized to include discussion of the mechanisms of oxidative phosphorylation and photosynthesis4. Fundamentals of Molecular BiologyAdditional discussion of real-time PCRNew discussion of the CRISPR/Cas system5. Genomics, Proteomics, and Systems BiologyNew chapter focusing on genomics, proteomics, and systems biologyAdded discussion of next-generation sequencingNew section on Synthetic BiologyNew Molecular Medicine: Malaria and Synthetic BiologyPart II. The Flow of Genetic Information6. Genes and GenomesUpdated discussion of noncoding RNAsNew Key Experiment: The ENCODE Project7. Replication, Maintenance, and Rearrangements of Genomic DNANew discussion of DNA rearrangement and yeast mating types8. RNA Synthesis and ProcessingDiscussion of the role of ?-ketoglutarate in catabolite repressionUpdated information on insulators and transcriptional domainsNew section on Chromatin and EpigeneticsUpdated discussion of lncRNAs9. Protein Synthesis, Processing, and RegulationNew discussion of prionsUpdated information on protein modification by ubiquitin and SUMONew Molecular Medicine: Alzheimer's DiseasePart III. Cell Structure and Function10. The NucleusNew information on the organization of chromosome domains within the nucleusUpdated discussion of nuclear bodies11. Protein Sorting and Transport: The Endoplasmic Reticulum, Golgi Apparatus, and LysosomesUpdated discussion of the insertion of membrane proteins in the ERNew information on protein trafficking through the GolgiUpdated discussion of vesicle docking and fusion12. Mitochondria, Chloroplasts, and PeroxisomesUpdated discussion of chloroplast genomes and protein importNew information on peroxisome biogenesisNew Molecular Medicine: Peroxisome Biogenesis Disorders13. The Cytoskeleton and Cell MovementUpdated discussion of actin filament remodeling at the leading edge14. The Plasma MembraneUpdated discussion of plasma membrane domains, lipid rafts and caveolaeNew information on clathrin-independent endocytosisUpdated Molecular Medicine to include new information on drug treatment of cystic fibrosis15. Cell Walls, the Extracellular Matrix, and Cell InteractionsNew discussion of the role of bacterial cytoskeletal proteins in cell wall synthesis and cell shapeUpdated information on a-catenin linkage to actinPart IV. Cell Regulation16. Cell SignalingChapter reorganized to focus on integrated signaling pathways17. The Cell CycleExpanded discussion of the initiation of DNA synthesis and role of APC/CNew information on the spindle assembly checkpoint18. Cell Death and Cell RenewalExpanded discussion of programmed cell death by autophagy and necroptosisNew information on stem cell niches19. CancerUpdated discussion of cancer genomicsNew information on targeted therapies