Biochemistry of Pulmonary Emphysema

C. Grassi, J. Travis, L. Casali, M. Luisetti (Herausgeber)

Buch | Softcover

200 Seiten

2014 | Softcover reprint of the original 1st ed. 1992
Springer London Ltd (Verlag)
978-1-4471-3773-3 (ISBN)

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Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

From the Contents: Pulmonary Emphysema: What's going on.- Elastin and the Lung.- An Introduction to the Endopeptidases.- Lung Proteinase and Emphysema.- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes.- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates.- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances.- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung.- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema.- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy.- Neutrophils, Neutrophil Elastase and the Fragile Lung.

Reihe/Serie	Current Topics in Rehabilitation
Vorwort	R. Corsico
Zusatzinfo	13 Illustrations, black and white; XV, 200 p. 13 illus.
Verlagsort	England
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Geisteswissenschaften ► Psychologie ► Klinische Psychologie
	Medizin / Pharmazie ► Gesundheitsfachberufe
	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Rehabilitation
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-4471-3773-6 / 1447137736
ISBN-13	978-1-4471-3773-3 / 9781447137733
Zustand	Neuware