Models of Seizures and Epilepsy (eBook)
712 Seiten
Elsevier Science (Verlag)
978-0-08-045702-4 (ISBN)
? The first comprehensive description of animal models of epilepsy since the early 1970's
? Comprehensive analysis of What the models model to guide the selection of each model, and what specific questions it will answer
? Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research
? World expert opinions on the clinical relevance of each model
An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research. - The first comprehensive description of animal models of epilepsy since the early 1970's- Comprehensive analysis of "e;What the models model"e; to guide the selection of each model, and what specific questions it will answer- Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research- World expert opinions on the clinical relevance of each model
Table of Contents 7
Contributing Authors 11
Foreword 15
Preface 17
CHAPTER 1: What Should Be Modeled? 19
CHAPTER 2: Single Nerve Cells Acutely Dissociated from Animal and Human Brains for Studies of Epilepsy 33
CHAPTER 3: Cell Culture Models for Studying Epilepsy 41
CHAPTER 4: An Overview of In Vitro Seizure Models in Acute and Organotypic Slices 53
CHAPTER 5: The Use of Brain Slice Cultures for the Study of Epilepsy 63
CHAPTER 6: Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research 77
CHAPTER 7: Thalamic, Thalamocortical, and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures 91
CHAPTER 8: Studying Epilepsy in the Human Brain In Vitro 107
CHAPTER 9: In Vitro Isolated Guinea Pig Brain 121
CHAPTER 10: Pharmacologic Models of Generalized Absence Seizures in Rodents 129
CHAPTER 11: Models of Chemically-Induced Acute Seizures 145
CHAPTER 12: Electrical Stimulation-Induced Models of Seizures 171
CHAPTER 13: Alcohol Withdrawal Seizures 179
CHAPTER 14: Alumina Gel Injection Models of Epilepsy in Monkeys 197
CHAPTER 15: Modeling Epilepsy and Seizures in Developing Zebrafish Larvae 207
CHAPTER 16: Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in Mice 217
CHAPTER 17: Spontaneous Epileptic Mutations in the Mouse 241
CHAPTER 18: Genetic Models of Absence Epilepsy in the Rat 251
CHAPTER 19: Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology 267
CHAPTER 20: Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibil 279
CHAPTER 21: Inherited Epilepsy in Mongolian Gerbils 291
CHAPTER 22: The Cortical Freeze Lesion Model 313
CHAPTER 23: MAM and Other “Lesion” Models of Developmental Epilepsy 323
CHAPTER 24: In Utero Irradiation as a Model of Cortical Dysplasia 333
CHAPTER 25: Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period 341
CHAPTER 26: Complex Febrile Seizures—An Experimental Model in Immature Rodents 351
CHAPTER 27: Repetitive Seizures in the Immature Brain* 359
CHAPTER 28: The Kindling Phenomenon 369
CHAPTER 29: Kindling Kittens and Cats 383
CHAPTER 30: Electrical Kindling in Developing Rats 389
CHAPTER 31: Chemical Kindling 397
CHAPTER 32: Kindling, Spontaneous Seizures, and the Consequences of Epilepsy: More Than a Model 413
CHAPTER 33: Tetanus Toxin Model of Focal Epilepsy 425
CHAPTER 34: Kainate-Induced Status Epilepticus: A Chronic Model of Acquired Epilepsy 433
CHAPTER 35: The Pilocarpine Model of Seizures 451
CHAPTER 36: Status Epilepticus: Electrical Stimulation Models 467
CHAPTER 37: Posttraumatic Epilepsy Induced by Lateral Fluid-Percussion Brain Injury in Rats 483
CHAPTER 38: Chronic Partial Cortical Isolation 495
CHAPTER 39: Head Trauma: Hemorrhage-Iron Deposition 513
CHAPTER 40: Stroke 519
CHAPTER 41: Models Available for Infection-Induced Seizures 539
CHAPTER 42: Brain Tumor and Epilepsy: A New Neurophysiologic and Neuropathologic Ex Vivo In Vitro Model 545
CHAPTER 43: An Animal Model of Rasmussen’s Encephalitis 553
CHAPTER 44: Therapeutic Assays for the Identification and Characterization of Antiepileptic and Antiepileptogenic Drugs 557
CHAPTER 45: Animal Models of Drug-Refractory Epilepsy 569
CHAPTER 46: Monitoring for Seizures in Rodents 587
CHAPTER 47: Imaging Approaches in Small Animal Models 601
CHAPTER 48: Behavioral Characterization of Seizures in Rats 619
CHAPTER 49: Behavioral and Cognitive Testing Procedures in Animal Models of Epilepsy 631
CHAPTER 50: Morphologic Approaches to the Characterization of Epilepsy Models 647
CHAPTER 51: Animal Model Development Based on the Human Epilepsies: Which Causes and Syndromes Should Be Modeled? 671
CHAPTER 52: What Good Are Animal Models? 677
Index 687
Contributing Authors
Massimo Avoli
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
Roy A. Bakay
Department of Neurological Surgery, Chicago Institute of Neurosurgery and Neuroresearch, Rush Presbyterian-St. Luke’s Medical Center, Chicago, IL
Scott C. Baraban
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA
Tallie Z. Baram
Departments of Pediatrics and Anatomy and Neurobiology, University of California Irvine, Irvine, CA
Stefania Bassanini
National Neurological Institute Carlo Besta, Milan, Italy
Giorgio Battaglia
National Neurological Institute Carlo Besta, Milan, Italy
Christophe Bernard
INMED-INSERM U29, Marseilles, France
Edward H. Bertram
Department of Neurology, University of Virginia, Charlottesville, VA
Ronald A. Browning
Department of Physiology, Southern Illinois University School of Medicine, Springfield, IL
Paul S. Buckmaster
Department of Comparative Medicine, Stanford University, Stanford, CA
Daniel L. Burgess
Department of Neurology, Baylor College of Medicine, Houston, TX
Thomas Budde
Institut fur Physiologie, Otto-von-Guericke-Universitat, Universitatsklinikum, Magdeburg, Germany
Xiang Cai
Department of Physiology, University of Maryland, Baltimore, MD
Esper A. Cavalheiro
Escola Paulista de Medicina (UNIFESP/EPM), Laboratorio de Neurologia Experimental, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Wei-Ping Chen
Department of Physiology and Pharmacology, SUNY Health Science Center, Brooklyn, NY
Suzanne Clark
Department of Biomedical Science, Colorado State University, Fort Collins, CO
Miguel A. Cortez
Department of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada
Marco de Curtis
Department of Experimental Neurophysiology, Instituto Nazionale Neurologico Carlo Besta, Milan, Italy
Antoine Depaulis
Université Joseph Fourier, Grenoble, France
Marc A. Dichter
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA
Céline Dinocourt
Department of Physiology, University of Maryland, Baltimore, MD
Céliné M. Dubé
Department of Anatomy and Neurobiology, University of California Irvine, Irvine, CA
F. Edward Dudek
Department of Physiology, University of Utah, Salt Lake City, UT
Jerome Engel, Jr.
Reed Neurological Research Center, Department of Neurology, UCLA School of Medicine, Los Angeles, CA
Aristea S. Galanopoulou
Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY
Mary E. Gilbert
Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, NC
Jeffrey H. Goodman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY
Ali Gorji
Institut fur Physiologie, Universitat Munster, Munster, Germany
Heidi Grabenstatter
Department of Biomedical Science, Colorado State University, Fort Collins, CO
Kevin D. Graber
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA
Uwe Heinemann
Institute of Neurophysiology, Charite, Humboldt University, Berlin, Germany
Gregory L. Holmes
Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH
John R. Huguenard
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA
John G.R. Jefferys
Department of Neurophysiology, University of Birmingham Medical School, Birmingham, United Kingdom
Frances E. Jensen
Department of Neurology, Children’s Hospital, Harvard Medical School, Boston, MA
Phillip C. Jobe
Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, Peoria, IL
Oliver Kann
Institute of Neurophysiology, Charite, Humboldt University, Berlin, Germany
Kevin M. Kelly
Department of Neurology, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA
Irina Kharatishvilli
Department of Neurobiology, AI Virtanen Institute for Molecular Science, University of Kuopio, Kuopio, Finland
Rüdiger Köhling
University of Rostock, Institute of Physiology, Rostock, Germany
Hana Kubová
Institute of Physiology, Academy of Sciences, Videnska, Prague, Czech Republic
Sanjay S. Kumar
Department of Comparative Medicine, Stanford University, Stanford, CA
João P. Leite
Department of Neurology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Laura Librizzi
Department of Experimental Neurophysiology, Instituto Nazionale Neurologico Carlo Besta, Milan, Italy
Dean D. Lin
Brain Institute, Department of Neurological Surgery, University of Florida, Gainesville, FL
Wolfgang Löscher
Department of Pharmacology, Toxicology & Pharmacy, School of Veterinary Medicine, Hannover, Germany
Joseph J. LoTurco
Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT
Heiko J. Luhmann
Institut fur Physiologie und Pathophysiologie, Johannes-Gutenberg-Mainz Universitat, Mainz, Germany
Gilles van Luijtelaar
Department of Biological Psychology, Radboud University of Nijmegen, Nijmegen, The Netherlands
Pavel Mareš
Institute of Physiology, Academy of Sciences, Videnska, Prague, Czech Republic
Gary W. Mathern
Department of Neurological Surgery, University of California Los Angeles, Los Angeles, CA
Andrey M. Mazarati
University of California Los Angeles, West Los Angeles VA Medical Center, Los Angeles, CA
Tracy K. McIntosh
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA
Dan C. McIntyre
Department of Psychology, Carleton University, Ottawa, Ontario, Canada
James O. McNamara
Department of Neurobiology, Duke University Medical Center, Durham, NC
Luiz E. Mello
Department of Physiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Solomon L. Moshé
Departments of Neurology, Neuroscience and Pediatrics, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
Maria G. Naffah-Mazzacoratti
Escola Paulista de Medicina (UNIFESP/EPM), Laboratorio de Neurologia Experimental, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Astrid Nehlig
Faculty of Medicine, University of Strasbourg, Strasbourg, France
Prosper N’Gouemo
Department of Pharmacology, Georgetown University Medical Center, Washington, DC
Jari Nissinen
Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
Jeffrey L. Noebels
Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX
Michael W. Nestor
Department of Physiology, University of Maryland, Baltimore, MD
Andre Obenaus
Department of Radiation Medicine, Radiobiology Program, Loma Linda University, Loma Linda, CA
Jeffrey Ockuly
Department of Neurology, University of Wisconsin, Madison, WI
Hans-Christian Pape
Institut fur Physiologie, Otto-von-Guericke-Universitat, Universitatsklinikum, Magdeburg, Germany
Asla Pitkänen
Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
John Pollard
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA
David A. Prince
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA
Dominick P. Purpura
Dean, Albert Einstein College of Medicine, Bronx, NY
Raddy L. Ramos
Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT
Charles E. Ribak
Department of Anatomy and Neurobiology, University of California Irvine, Irvine, CA
Michael A. Rogawski
Epilepsy Research Section, Porter Neuroscience Research...
| Erscheint lt. Verlag | 4.10.2005 |
|---|---|
| Sprache | englisch |
| Themenwelt | Sachbuch/Ratgeber |
| Geisteswissenschaften ► Psychologie ► Klinische Psychologie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| ISBN-10 | 0-08-045702-9 / 0080457029 |
| ISBN-13 | 978-0-08-045702-4 / 9780080457024 |
| Haben Sie eine Frage zum Produkt? |
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