Roles of Vasopressin and Oxytocin in Memory Processing (eBook)

Cover 1
Copyright Page 5
Contents 14
Preface 42
Part I 48
Chapter 1. General Introduction to Vasopressin and Oxytocin: Structure/Metabolism, Evolutionary Aspects, Neural Pathway/Receptor Distribution, and Functional Aspects Relevant to Memory Processing 48
I. Metabolic Aspects 48
II. Evolutionary Considerations and Comparative Study 53
III. VP and OT Cell Systems, Pathways, and Receptors: Characteristics and Distribution 56
IV. Functional Aspects Relevant to Memory Processing: Actions at Nonneural Receptor Sites 85
Part II 98
Chapter 2. De Wied and Colleagues I: Evidence for aVPand an OT Influence on MP: Launching the ‘‘VP/OT Central Memory Theory’’ 98
I. Chapter Overview 98
II. Major Task Paradigms Used by De Wied and Associates in Their VP/OT Memory Research 99
III. Role for Vasopressin in Facilitating Memory Consolidation and Retrieval 102
IV. Oxytocin: A Natural Amnestic in Aversive Learning Situations 125
V. Effects of VP on Retrograde Amnesia: Effect on Memory Retrieval? 137
VI. VP and OT Appear to Have No Important Effects on the Learning Phase of Memory Processing 141
VII. Theoretical Propositions of the ‘‘VP/OT Central Memory Theory’’ and Relevant Evidence 144
Chapter 3. De Wied and Colleagues II: Further Clarification of the Roles of Vasopressin and Oxytocin in Memory Processing 150
I. Chapter Overview 150
II. Establishing the Roles of Endogenous VP in Memory Processing: The Brattleboro Rat Model 151
III. Further Study of the Role of Endogenous VP and OT in Memory Processing: Peripheral and/or Central Mechanisms? 163
IV. Vasopressin-Induced Increase in Behavioral Arousal Is Not Essential for Its Effect on Memory Processing 176
V. Peripherally Administered Neurohypophysial Peptides and Central Memory Processing 180
VI. Theoretical Propositions of the ‘‘VP/OT Central Memory Theory’’: Continued 181
Chapter 4. De Wied and Colleagues III: Brain Sites and Transmitter Systems Involved in theVasopressin and Oxytocin Influence on Memory Processing 188
I. Introductory Remarks 188
II. Localizing Central Sites for the Memory-Modulating Effects of VP and OT by Means of Lesioning and Microinjection Techniques 188
III. Interaction between VP/OT Peptides and Brain Catecholamines in Memory Processing 202
IV. Interaction between VP and Catecholamines of Peripheral Origin during Memory Processing 216
V. Theoretical Propositions of the ‘‘VP/OT Central Memory Theory’’: Continued 220
Chapter 5. De Wied and Colleagues IV: Research into Mechanisms of Action by Which Vasopressin and Oxytocin Influence Memory Processing 224
I. Chapter Overview 224
II. VP and OT: Precursors of Metabolic Fragments That Exert Memory-Modulating Effects in the Brain? 225
III. Characterizing the Brain Receptors That Mediate the Effects of VP and OT on Memory Processing 240
IV. VP, OT, and Hippocampal Theta Rhythm during Paradoxical Sleep 242
V. Effects of VP and OT on Neuronal Activities in the Septal–Hippocampal System, and Memory Processing 251
VI. Theoretical Propositions of the ‘‘VP/OT Central Memory Theory’’: Concluded 267
Part III 274
Chapter 6. Research Studies of Koob and Colleagues: The ‘‘Vasopressin Dual Action Theory’’ 274
I. Overview 274
II. Memory Tasks Used in VP/Memory Research 276
III. Studies with Pole-Jump Active Avoidance, and Single-Trial Passive Avoidance Paradigms 278
IV. Aversive Effects of Behaviorally Active Doses of Peripherally Administered VP 287
V. Research Studies with the Single-Trial Water (Food)-Finding Task 292
VI. Research Study with the Radial Maze Task 297
VII. Physiological Research 300
VIII. The ‘‘VP Dual Action Theory’’ 303
IX. The Theoretical Controversy between the De Wied et al. and Koob et al. Research Groups 308
X. Commentary Relevant to the Koob et al. Position 310
Chapter 7. Contributions of Sahgal and Colleagues: The ‘‘Vasopression Central Arousal Theory’’ 312
I. Chapter Overview 312
II. Behavioral Arousal and Central Arousal System Constructs, and Their Relevance for Cognitive Behavior 313
III. Relationship Between the ‘‘VP Central Arousal Theory’’ and the ‘‘VP Dual Action Theory’’ 318
IV. Sahgal’s Critique of the Research Practices of De Wied and Colleagues 319
V. Research Practices and Objectives of Sahgal and Colleagues 320
VI. Task Paradigms and Research Findings 321
VII. Chapter Summary and Commentary on the ‘‘VP Central Arousal Theory’’ 337
Part IV 342
Chapter 8. Role of Attentional Processing in Mediating the Influence of Vasopressin on Memory Processing 342
I. Introductory Remarks 342
II. Beckwith and Colleagues 343
III. Vasopressin and Attentional Processing: Bunsey, Strupp, and Colleagues 362
IV. Other Lines of Evidence Supporting a Role for Vasopressin in Attentional Processing 373
V. Research Summaries: Beckwith and Colleagues, and Bunsey, Strupp, and Colleagues 379
VI. Chapter Commentary: Vasopressin, Attention, and Memory Processing 382
Part V 386
Chapter 9. Expansion of Vasopressin/Oxytocin Memory Research I: Peripheral Administration 386
I. Introductory Remarks 386
II. Animal Research Literature 387
III. Human Research Literature 427
Chapter 10. Expansion of Vasopressin/Oxytocin Memory Research II: Brain Structures and Transmitter Systems Involved in the Influence of Vasopressin and Oxytocin on Memory Processing 436
I. Chapter Overview 436
II. Central Neural Structures Involved in VP and/or OT Effects on Memory Processing 437
III. VP and/or OT Interaction with Central Neurotransmitter Systems and Memory Processing 452
IV. Endogenous AVP and/or OT and Memory Processing 462
Chapter 11. Expansion of Vasopressin/Oxytocin Memory Research III: Research Summary and Commentary on Theoretical and Methodological Issues 468
I. Introductory Remarks 468
II. Research Summary 1: Peripherally Administered VP and/or OT and Memory Processing„Studies Reviewed in Chapter 9 469
III. Research Summary 2: Central Aspects of VP-ergic and OT-ergic Involvement in Memory Processing„Studies Reviewed in Chapter 10 481
IV. Controversial Issues Concerning Interpretation of the In.uence of Peripherally Administered VP on Learning/Memory Tasks 488
V. Methodological Issues: Subject, Treatment, and/or Task Variables May Affect the Outcome or Interpretation of Experimental Studies on VP/ Memory Research 491
Part VI 500
Chapter 12. Research Contributions of Dantzer, Bluthe, and Colleagues to the Study of the Role of Vasopressin in Olfactory-Based Social Recognition Memory 500
I. Overview 500
II. The Olfactory-Based Social Recognition Memory Task 501
III. Research Findings 502
IV The ‘‘VP Dual Action Theory’’ and Olfactory-Based SRM 515
V Commentary I: Roles of VP in Mediating Olfactory-Based SRM 517
VI Commentary II: Contribution of the California/Bordeaux Research Teams in VP Memory Research 520
Chapter 13. Expansion of Olfactory-Based Social Recognition Memory Research: The Roles of Vasopressin and Oxytocin in Social Recognition Memory 522
I. Introductory Remarks 522
II. Test Paradigms for Assessing SRM 522
III. Effects of Peripherally and/or Centrally Administered VP, OT, or Their Metabolic Fragments on SRM in Laboratory Rats and Mice 524
IV. Sex Differences and the VP/OT In.uence on SRM 537
V. Influence of Septal–Hippocampal VP and OT on SRM 542
VI. VP/OT and the Olfactory System 556
VII. VP and OT in the Medial Preoptic Area and SRM 563
VIII. VP and OT Genetic Knockout Models and SRM 565
IX. Chapter Summary and Commentary 571
Part VII 578
Chapter 14. Brain–Fluid Barriers: Relevance for Theoretical Controversies Regarding Vasopressin and Oxytocin Memory Research 578
I. Chapter Overview 578
II. Brain–Fluid Barriers: Blood-Brain Barrier and Blood–Cerebrospinal Fluid Barrier 579
III. Origin and Fate of VP and OT within the CSF 590
IV. Means by Which Peripherally Injected VP and OT Might Induce Behavioral Effects 596
V. Research Relevant to the View That Peripherally Circulating AVP Can Penetrate Brain-Fluid Barriers 601
VI. AVP Influences Permeability of Brain–Fluid Barrier to Nutrient Transport 622
VII Chapter Summary and Commentary 637
Part VIII 640
Chapter 15. Closing Remarks: Review and Commentary on Selected Aspects of the Roles of Vasopressin and Oxytocin in Memory Processing 640
I. Chapter Overview 640
II. In Retrospect: Historical Highlights in the Study of the Roles of VP and OT in Memory Processing 641
III. VP and OT and Memory Processing: Avoidance and Appetitive Learning Paradigms 642
IV. VP, OT, and Rodent Olfactory-Based Social Recognition Memory 681
V. Closing Remarks: Future Considerations 694
References 702
Index 756
Contents of Previous Volumes 774
Color Plate Section 788