Revisiting Barrett's Esophagus (eBook)

After completing his medical school degree, Professor Giuseppe Galloro earned his post-graduate specialization in General Surgery, both with honors. Following his post-graduate training as a junior doctor at the General Surgery Department of the University of Naples Federico II - School of Medicine, he was appointed as assistant and then resident fellow at the same department. He later became a consultant at the Digestive Surgical Endoscopy Unit and Researcher in General Surgery. He was nominated as an Assistant Professor (2004) and Associated Professor (2015) of General Surgery at the University of Naples Federico II - School of Medicine, as well as head of the Diagnostic and Therapeutic Endoscopy of Non Neoplastic Diseases of the Digestive System, Biliary Tract and Pancreas Section at the same hospital. He currently teaches several graduate and post-graduate courses (on general surgery, digestive diseases, and digestive endoscopy). His main clinical and research practice is on new techniques and methodologies in diagnostic and operative endoscopy of pre neoplastic diseases and early digestive cancers; endoscopic management of obesity; computing applications and new materials applied to endoscopy. He has authored various volumes of congress proceedings, monographs and journal articles, and has been an invited speaker at over three hundred national and international congresses. 

Part IMorphologic backgrounds1Macroscopic anatomy of esophagusStefania Montagnani, Clotilde Castaldo2Microscopic anatomy and histology of esophagusStefania Montagnani, Franca Di MeglioPart IIEpidemiology and natural history3Definition and epidemiology of Barrett’s esophagusAlessandra Romiti, Rocco Maurizio Zagari4Pathophysiolgy of esophageal reflux disease and natural history of Barrett’s esophagusPaola Iovino, Antonella Santonicola, Nigel J TrudgillGastro-esophageal reflux diseaseNatural history of Barrett’s esophagusNatural history of non dysplastic Barrett’s esophagusNatural history of Barrett’s esophagus indefinite for dysplasiaNatural history of Barrett’s esophagus with low grade dysplasiaNatural history of Barrett’s esophagus with high grade dysplasia5Obesity: Barrett’s esophagus and esophageal cancer riskJan Marc Chevallier, Sonja Chiappetta, Mario MusellaIntroductionFactors leading to GERDObesity, Barrett’s ulcer, and risk of cancerBariatric surgery and risk of GERDGERD following restrictive proceduresGERD following gastric by-pass proceduresPart IIIDiagnosis6First level endoscopy in Barrett’s esophagus: endoscopic pictures, Prague classification and biopsy protocolsMassimo Conio, Antonella De Ceglie, Mattia CrespiEndoscopic picturesPrague classificationBiopsy protocol7Augmented endoscopy in Barrett’s esophagus: zoom endoscopy, traditional, and virtual chromoendoscopyGiuseppe Galloro, Raffaele Manta, Nico Pagano, Teresa Russo, Donato Alessandro Telesca, Andrea Parodi, Cesare FormisanoIntroductionTraditional chromoendoscopyHigh definition, zoom, and magnifying endoscopyComputed virtual chromoendoscopy8Confocal LASER endomicroscopy in Barrett’s esophagus: is it a clinical resource or still a research procedure?Giovanni Domenico De Palma, Gianluca Cassese, Gaetano LuglioConfocal LASER endomicroscopy: theoretical and practical basesTechnical notesCLE for Barrett’s esophagus managementCurrent limitations and possibilities for future developmentConclusions9Histology: the different points of view on Barrett’s esophagusVincenzo Villanacci, Karel Geboes, Tiziana Salviato, Gabrio BassottiNormal esophagusEndoscopic and microscopic diagnosis of Barrett’s esophagusIs all intestinal metaplasia equivalent to Barrett’s esophagus?Dysplasia in Barrett’s esophagus10The role of molecular biology in diagnosis and follow-up of Barrett’s esophagusKaren Geboes, Anne HoorensIntroductionMolecular pathways implicated in development of Barrett’s esophagusMolecular markers for the diagnosisMarkers for the diagnosis of dysplasiaGenome-wide association studies for the development of Barrett’s esophagusMolecular pathways implicated in the transition of Barrett’s esophagus to early adenocarcinomaMolecular biology of progression to adenocarcinomaMolecular markers for the diagnosis of progression to EAC.Genetic changes involved in the progression from BE to EAC. Biomarker developmentConclusions11Timing and protocols of clinical and endoscopic surveillance of Barrett’s esophagusCarlo Calabrese, Marco Salice, Nico Pagano, Raffaele Manta, Fernando RizzelloProtocolPart IVTreatments12Lifestyles, medical therapy, and chemopreventionGiancarlo Sarnelli, Alessandra D’Alessandro, Raf BisschopsPhysical activity and dietSmoking and alcohol intakeChemoprevention13Photodynamic therapyRaffaele Manta, Dolores Sgambato, Nico Pagano, Giuseppe GalloroIntroductionTechniqueData of literatureLimitsControindicationsState of the art14CryotherapyNico Pagano, Raffaele Manta, Giuseppe GalloroIntroductionPhysical principles and technical considerationClinical resultsConclusions15Endoscopic resections: EMR and ESDFilippo Catalano, Seichiro Abe, Yutaka Saito16Radiofrequency ablationJason Samarasena, David Lee, Kenneth J ChangIntroductionIndicationsEquipmentTechniquePost procedureEfficacyAdverse eventsCost-effectiveness analysisBuried Barrett’s EsophagusConclusions17What we have to do after the treatment of metaplasia or dysplasia in Barrett’s esophagus? Protocols and timing of follow-up in the treated patientJose Miguel EstebanIntroductionEndoscopic therapies of Barrett’s esophagusSurveillance after endoscopic therapySurveillance StrategiesPublications regarding Protocols and Timing for surveillanceProtocols and timing of follow-up in the treated patient recommendationsSpecial considerationsConclusions18Is there a role for the surgeon in therapeutic management of Barrett esophagus?Uberto Fumagalli Romario, Paul Magnus SchneiderIntroductionDoes BE regress after ARS and/or does ARS reduce the cancer risk in BE?Which type of surgery for short and long segment Barrett's esophagus ? Role of ARS to prevent BE remission following endoscopic ablation proceduresRole of ARS to prevent BE recurrence or progression after endoscopic ablation procedures19Early adenocarcinoma in Barrett esophagus: is this an endoscopic or a surgical problem?Antonello Trecca, Takuji Gotoda