Asymptotics of Elliptic and Parabolic PDEs (eBook)

and their Applications in Statistical Physics, Computational Neuroscience, and Biophysics
eBook Download: PDF
2018 | 1st ed. 2018
XXIII, 444 Seiten
Springer International Publishing (Verlag)
978-3-319-76895-3 (ISBN)

Lese- und Medienproben

Asymptotics of Elliptic and Parabolic PDEs - David Holcman, Zeev Schuss
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This is a monograph on the emerging branch of mathematical biophysics combining asymptotic analysis with numerical and stochastic methods to analyze partial differential equations arising in biological and physical sciences.

In more detail, the book presents the analytic methods and tools for approximating solutions of mixed boundary value problems, with particular emphasis on the narrow escape problem. Informed throughout by real-world applications, the book includes topics such as the Fokker-Planck equation, boundary layer analysis, WKB approximation, applications of spectral theory, as well as recent results in narrow escape theory. Numerical and stochastic aspects, including mean first passage time and extreme statistics, are discussed in detail and relevant applications are presented in parallel with the theory.

Including background on the classical asymptotic theory of differential equations, this book is written for scientists of various backgrounds interested in deriving solutions to real-world problems from first principles.



David Holcman is an applied mathematician and computational biologist. He developed mathematical modeling and simulations of molecular dynamics in micro-compartments in cell biology using stochastic processes and PDEs. He has derived physical principles of physiology at various scales, including diffusion laws in dendritic spines, potential wells hidden in super-resolution single particle trajectories or first looping time in polymer models. Together with Zeev Schuss, he developed the Narrow escape and Dire strait time theory.

Zeev Schuss is an applied mathematician who significantly shaped the field of modern asymptotics in PDEs with applications to first passage time problems. Methods developed have been applied to various fields, including signal processing, statistical physics, and molecular biophysics. 

David Holcman is an applied mathematician and computational biologist. He developed mathematical modeling and simulations of molecular dynamics in micro-compartments in cell biology using stochastic processes and PDEs. He has derived physical principles of physiology at various scales, including diffusion laws in dendritic spines, potential wells hidden in super-resolution single particle trajectories or first looping time in polymer models. Together with Zeev Schuss, he developed the Narrow escape and Dire strait time theory.Zeev Schuss is an applied mathematician who significantly shaped the field of modern asymptotics in PDEs with applications to first passage time problems. Methods developed have been applied to various fields, including signal processing, statistical physics, and molecular biophysics. 

Part I. Singular Perturbations of Elliptic Boundary Problems.- 1 Second-Order Elliptic Boundary Value Problems with a Small Leading Part.- 2 A Primer of Asymptotics for ODEs.- 3 Singular Perturbations in Higher Dimensions.- 4 Eigenvalues of a Non-self-adjoint Elliptic Operator.- 5 Short-time Asymptotics of the Heat Kernel.- Part II Mixed Boundary Conditions for Elliptic and Parabolic Equations.- 6 The Mixed Boundary Value Problem.- 7 THe Mixed Boundary Value Problem in R2.- 8 Narrow Escape in R3.- 9 Short-time Asymptotics of the Heat Kernel and Extreme Statistics of the NET.- 10 The Poisson–Nernst–Planck Equations in a Ball.- 11 Reconstruction of Surface Diffusion from Projected Data.- 12 Asymptotic Formulas in Molecular and Cellular Biology.- Bibliography.- Index.

Erscheint lt. Verlag 25.5.2018
Reihe/Serie Applied Mathematical Sciences
Zusatzinfo XXIII, 444 p. 103 illus., 56 illus. in color.
Verlagsort Cham
Sprache englisch
Themenwelt Mathematik / Informatik Mathematik
Naturwissenschaften Biologie
Naturwissenschaften Physik / Astronomie
Schlagworte applied conformal transformation • asymptotic formula • boundary value problems • eigenvalues • Eikonal equation • extreme statistics • first passage times • Green’s Functions • Helmholtz equation • Integral equations • long-time asymptotics • matched asymptotics • Narrow escape • Neumann’s function • non-self adjoint operators • Partial differential equations • Poisson-Nernst-Planck • Ray method • short-time asymptotics • WKB
ISBN-10 3-319-76895-6 / 3319768956
ISBN-13 978-3-319-76895-3 / 9783319768953
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