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Patient-Derived Xenograft Models of Human Cancer (eBook)

Yuzhuo Wang, Dong Lin, Peter W. Gout (Herausgeber)

eBook Download: PDF

2017 | 1st ed. 2017
XI, 204 Seiten
Springer International Publishing (Verlag)
978-3-319-55825-7 (ISBN)

Lese- und Medienproben

Ebook-Leseprobe (PDF)

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text.

Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.

Yuzhuo Wang, PhD

Director, Living Tumor Laboratory

Distinguished Scientist, BC Cancer Agency

Senior Scientist, Vancouver Prostate Centre

Professor, University of British Columbia

675 West 10th Avenue, Room 3.122

Vancouver, BC, Canada V5Z 1L3

604-675-8013, ywang@bccrc.ca

Dong Lin, PhD, MD

Research Pathologist, Living Tumor Laboratory

Vancouver, BC, Canada V5Z 1L3

604-675-8000, ext. 7011, dlin@bccrc.ca

Peter W. Gout, PhD

Scientific Consultant, Living Tumor Laboratory

Honorary Associate Professor, Department of Urologic Sciences, University of British Columbia

Emeritus Senior Scientist, Department of Experimental Therapeutics, BC Cancer Agency

<675 West 10th Avenue, Room 5.108

Vancouver, BC, Canada V5Z 1L3

604-675-8000, ext. 8026, pgout@bccrc.ca

Yuzhuo Wang, PhDDirector, Living Tumor LaboratoryDistinguished Scientist, BC Cancer AgencySenior Scientist, Vancouver Prostate CentreProfessor, University of British Columbia675 West 10th Avenue, Room 3.122Vancouver, BC, Canada V5Z 1L3Dong Lin, PhD, MDResearch Pathologist, Living Tumor LaboratoryPeter W. Gout, PhDScientific Consultant, Living Tumor LaboratoryHonorary Associate Professor, Department of Urologic Sciences, University of British ColumbiaEmeritus Senior Scientist, Department of Experimental Therapeutics, BC Cancer AgencyVancouver, BC, Canada V5Z 1L3

Section I: IntroductionHistory and Evolution of PDX Cancer ModelsSection II: Establishment and Characterization of PDX ModelsMethods of Generating PDX ModelsFidelity and Stability of PDX ModelsSection III: Applications of PDX ModelsStudies of Cancer HeterogeneityPDX and Cancer Stem CellsModeling Cancer MetastasisModeling Drug ResistancePDX and Biomarker DevelopmentPDX and Preclinical Drug ScreeningCo-clinical Trials and Personalized Cancer Therapy/Precision MedicineSection IV: EpilogueFuture Perspective.

Erscheint lt. Verlag	27.6.2017
Reihe/Serie	Molecular and Translational Medicine
Zusatzinfo	XI, 204 p. 27 illus., 26 illus. in color.
Verlagsort	Cham
Sprache	englisch
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Schlagworte	cancer heterogeneity • Modeling cancer metastasis • Modeling drug resistance • PDX and biomarker development • PDX cancer models
ISBN-10	3-319-55825-0 / 3319558250
ISBN-13	978-3-319-55825-7 / 9783319558257

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