Biomaterials Associated Infection (eBook)
XIV, 566 Seiten
Springer New York (Verlag)
978-1-4614-1031-7 (ISBN)
Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.
Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.
Preface PART 1. The Pathogenesis of Medical Device associated InfectionChapter 1: Biomaterial associated infection: a perspective from the clinicChapter 2: Staphylococcus epidermidis in biomaterial associated infectionChapter 3: Staphylococcal virulence factorsChapter 4: Propionibacterium acnes: a new emerging pathogen in biomaterial associated infectionChapter 5: Bridging the gap between in vitro and in vivo testing for Biomaterial associated infectionChapter 6: Biomaterial-dependent characteristics of the foreign body response and S. epidermidis biofilm interactionsChapter 7: Dendritic cell-biomaterial interactions: implications for the onset and development of the foreign body responseChapter 8: Tissue Colonisation in Biomaterial-Associated InfectionChapter 9: Treatment options for medical device associated infectionChapter 10: Novel antimicrobial strategies: honey and antimicrobial peptidesChapter 11: Infections associated with implanted dental devicesChapter 12: Animal models of orthopedic implant related infection PART 2: Biomaterial-based Strategies to Reduce Medical Device Associated InfectionChapter 13: Antimicrobial medical devices in preclinical development and clinical useChapter 14: Silver containing biomaterialsChapter 15: Quaternary ammonium CompoundsChapter 16: Anti-adhesive and Antibacterial Polymer BrushesPART 3: Clinical applications, case studiesChapter 17: Orthopaedic device design and antibiotic coatings reduce infection ratesChapter 18: The indwelling bladder catheter: attempts to prevent infection and the development of bacterial biofilmsChapter 19: Antimicrobial-Modified Vascular CathetersChapter 20: Topical Antimicrobial Containing Biomaterials for Peri-Implant Infections in the Oral CavityChapter 21: Preventive Strategies in VAP: Focus on Silver-Coated Endotracheal Tubes IndexPART 3: Clinical applications, case studiesChapter 17: Orthopaedic device design and antibiotic coatings reduce infection ratesChapter 18: The indwelling bladder catheter: attempts to prevent infection and the development of bacterial biofilmsChapter 19: Antimicrobial-Modified Vascular CathetersChapter 20: Topical Antimicrobial Containing Biomaterials for Peri-Implant Infections in the Oral CavityChapter 21: Preventive Strategies in VAP: Focus on Silver-Coated Endotracheal Tubes Index
| Erscheint lt. Verlag | 29.9.2012 |
|---|---|
| Zusatzinfo | XIV, 566 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie |
| Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Naturwissenschaften ► Biologie | |
| Naturwissenschaften ► Chemie | |
| Technik ► Bauwesen | |
| Technik ► Maschinenbau | |
| Technik ► Medizintechnik | |
| Schlagworte | Anti-adhesive and Antibacterial Polymer Brushes • Anti-adhesive and Antibacterial Polymer Brushes • Antibacterial biomaterials • Antibiotic coating device • Antibiotic release • Anti-infective material • Antimicrobial biomaterials • Antimicrobial coating device • Antimicrobial device • Antimicrobial-Modified Vascular Catheters • Bai • biofilm formation biomaterial • biomaterial antimicrobials • biomaterial associated infection • Biomaterial dendritic cell interactions • biomaterial implanted biomaterials immunology • Coagulase negative staphylococci infection • Colonization of tissue surrounding inserted medical devices • Dendritic cell-biomaterial interactions • foreign body response • immune function implanted biomaterial • immune response implanted • Implant associated infection • indwelling bladder catheter • indwelling bladder catheter infection • Infection of inserted or implanted medical devices • intracellular bacteria • Medical device associated infection • Peri-implantitis biofilm • Peri-implant tissue colonization • Preventive Strategies in VAP • propionibacterium acnes • Quaternary ammonium Compounds • race for the surface • Rifampin biofilm • S. epidermidis biofilm interactions • S. epidermidis/ S. aureus biofilm • Silver containing biomaterials • Staphylococcal virulence factors • Staphylococcus aureus • Staphylococcus aureus implant associated infection • Staphylococcus aureus infection of implanted medical devices • Staphylococcus aureus medical device associated infection • Staphylococcus Epidermidis • Staphylococcus epidermidis implant associated infection • Staphylococcus epidermidis infection of inserted medical devices • Staphylococcus epidermidis medical device associated infection • tissue colonisation in BAI • tissue infection |
| ISBN-10 | 1-4614-1031-2 / 1461410312 |
| ISBN-13 | 978-1-4614-1031-7 / 9781461410317 |
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