Modern Avenues in Metal-Nucleic Acid Chemistry

Jens Müller holds a Chair of Inorganic Chemistry (2018) at the Department of Chemistry and Pharmacy, Westfälische Wilhelms-Universität Münster, Germany. He obtained his doctoral degree (1999, summa cum laude) from the Technische Universität Dortmund, working with Bernhard Lippert. After a postdoctoral stay in the groups of Stephen J. Lippard (MIT) and Gerhard Wagner (Harvard Medical School), he started his independent career at the Technische Universität Dortmund in 2002, funded by the prestigious Emmy Noether Programme. After having received his Habilitation in 2008, he became Professor of Inorganic Chemistry at the Westfälische Wilhelms-Universität Münster. His research focuses on the bioinorganic chemistry of nucleic acids, with a particular interest in metal-mediated base pairing. He was Dean of Student Affairs from 2011–2014, Chair of the European research initiative COST Action CM1105 ("Functional metal complexes that bind to biomolecules"), and guest Editor of several themed issues of chemistry journals. Since 2018, he has served as the Editor of Inorganica Chimica Acta. He is the Chair of EuroBIC-17 (2024 in Münster, Germany). Bernhard Lippert retired in 2011 from Chair of Bioinorganic Chemistry at the Technische Universität Dortmund, Germany. He received his Ph.D. degree from Technische Universität München (TUM), Germany, in 1974. Following a postdoctoral stay with Barnett Rosenberg at the Biophysics Department of Michigan State University, USA, he started his independent research at TUM, which was focused on fundamental aspects of interactions of metal species, notably of Pt, with nucleobases, as well as supramolecular constructs derived from these components. During his career at TUM, the University of Freiburg, Germany, and TU Dortmund, he has trained 70 PhD students and in addition numerous Bachelor and Master students as well as postdoctoral fellows, a fair number of whom eventually earned academic positions. Results of his group’s work are documented in over 400 refereed scientific articles and have been communicated at many international conferences and lectureships. He served the community as Editorial Board member of several journals (Inorg. Chem., Dalton Trans., Inorg. Chim. Acta, J. Biol. Inorg. Chem., Biometals), and was the Editor of Inorg. Chim. Acta from 2008 to 2019. He was (Co)-Editor of a number of themed issues in chemistry journals, and Editor of the book Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, which reviewed the knowledge on Pt antitumor complexes at the turn of the century. He has been involved in the management of European research activities in the COST frame, has been the Secretary of EuroBIC conferences for 11 years and has organized numerous scientific meetings such as the "EURESCO Research conference on the Inorganic Side of Molecular Architecture" (2002), EuroBIC-7 (2004), and "4th EuCheMS Conference on Nitrogen Ligands" (2008), among others. Since 2014 he has been an Honorary Member of the Society of Biological Inorganic Chemistry (SBIC).

Chapter 1 Porous Materials Built Up From Metal-Nucleobase Materials

Garikoitz Beobide, Oscar Castillo, Antonio Luque, and Sonia Pérez-Yáñez

Chapter 2 Cytosine and Its Derivatives as Useful Tools to Build Unusual and Fascinating Architectures

Teresa F. Mastropietro and Giovanni De Munno

Chapter 3 Coordination Polymers with Nucleobase Derivatives: From Electronic Nanodevices to Sensors

Noelia Maldonado and Pilar Amo-Ochoa

Chapter 4 Heavy Coinage Metal Nucleobase, Nucleoside and (Oligo)Nucleotide Systems: Recent Developments in Self-assembly, Opto-electronics, and DNA Integration

Andrew Houlton

Chapter 5 Interplay between Noncovalent Interactions and Metal Ions in Nucleic Acids and Their Constituents

Miquel Barceló-Oliver, Antonio Frontera, Juan Jesús Fiol, Ángel García-Raso, and Ángel Terrón

Chapter 6 Biological Implications of Metal-Nucleobase Complexes

Saurabh Joshi, Ankita Jaiswal, Rajneesh Kumar Prajapati, and Sandeep Verma

Chapter 7 Stimuli-Responsive DNA-Binding Metal Complexes

Tim Kench and Ramon Vilar

Chapter 8 How Do Cationic Pt(II) Complexes Modify the Higher-Order Structure of DNA?

Seiji Komeda, Masako Uemura, Yuko Yoshikawa, and Kenichi Yoshikawa

Chapter 9 Metals in Genotyping: From SNPs to Sequencing

Tuomas Lönnberg

Chapter 10 Nucleic Acids for the Preparation and Control of Continuous Hybrid Metallic Assemblies

Miguel A. Galindo, Fátima Linares, Alicia Domínguez-Martín, and Antonio Pérez-Romero

Chapter 11 Recent Advances in the Development of Metal-Responsive Functional DNAs Based on Metal-Mediated Artificial Base Pairing

Yusuke Takezawa and Mitsuhiko Shionoya

Chapter 12 Nucleic Acid-Templated Metal Nanoclusters

Rweetuparna Guha and Stacy M. Copp

Chapter 13 G-Quadruplex Nucleic Acids and the Role of Metal Ions: Insights from Quantum Chemical Bonding Analyses

Celine Nieuwland and Célia Fonseca Guerra

Chapter 14 Transition Metal-Binding G-Quadruplex DNA

Lukas M. Stratmann and Guido H. Clever

Chapter 15 Metabolite Regulation by Riboswitches: The Role of Metal Ions in Folding, Ligand Binding, and Functionality

Maria Reichenbach, Sofia Gallo, and Roland K.O. Sigel

Index