RNA Damage and Repair

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About the Editor: Dr Ioly Kotta-Loizou is currently a Research Associate in the Department of Life Sciences, Imperial College London, UK. She is also a Visiting Lecturer at University of Hertfordshire and an Honorary Lecturer at University of Manchester. She holds a BSc in Biology, a MSc in Bioinformatics and a PhD in Molecular Microbiology from the University of Athens, Greece. Ioly has a keen interest in microorganisms and her studies focus on microbial life cycles and pathogenicity, together with potential applications in medicine and agriculture. Currently, she investigates RNA expression, damage and repair in bacteria, and how these processes can be linked to antibiotic resistance. In parallel, she explores how RNA viruses found in pathogenic fungi targeting humans, plants or insects can potentially be used in biological control. Ioly is a Fellow of the Higher Education Academy, and teaches next-generation sequencing and virology to undergraduate and postgraduate students. She is a member of the RNA Society, an Editor for the scientific journals Archives of Virology, Viruses, Pathogens, Microorganisms and Frontiers, and a Chair in the International Committee on Taxonomy of Viruses.

Part 1: RNA Damage and Repair in Prokaryotes.- Chapter 1: Endoribonucleases of the toxin-antitoxin systems induce abortive infection.- Chapter 2: The lifecycle of ribosomal RNA in bacteria.- Chapter 3: The Rtc RNA end healing and sealing system.- Part 2: RNA Damage and Repair in Eukaryotes.- Chapter 4: Oxidative and nitrative RNA modifications in plants.- Chapter 5: The role of ribonucleases in RNA damage, inactivation, and degradation.- Chapter 6: Cytoplasmic mRNA recapping: An unexpected form of RNA repair.-  Part 3: RNA Damage in Human Diseases.- Chapter 7: Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases.- Chapter 8: RNA-mediated metabolic defects in microsatellite expansion diseases.