Nanotechnology for Oral Drug Delivery

João Pedro Martins graduated in Biomedical Engineering at the Faculty of Engineering of the University of Porto (FEUP) in collaboration with the Institute of Biomedical Engineering (INEB), Porto, Portugal. Currently, he is a fourth-year PhD student at the Faculty of Pharmacy of the University of Helsinki, Finland. In the framework of his PhD, J.P. Martins is developing advanced drug delivery systems with the aim of making oral administration of nanomedicines carrying anti-diabetic drugs a reality. So far, he has authored/co-authored 12 scientific publications (original and review articles), 2 book chapters, and 1 conference proceedings, and has given 8 oral communications and 13 poster presentations in scientific meetings. J.P. Martins has more than 150 citations (Google Scholar 190; h-index = 8), and has also served as a reviewer for 7 international peer-reviewed scientific journals. Prof. Santos (D.Sc. Tech., Chem. Eng.) is a Full Professor in Department of Biomedical Engineering at the University of Groningen. He is also Research Director at the University of Helsinki, Faculty of Pharmacy. Prof. Santos is also the co-founder of the startups Capsamedix Oy and Medixmicro Oy, and Coordinator of MSCA-ITN P4 FIT network in tendon repair (~4.1 m€). He holds Visiting Professorships at the Shanghai Jiao Tong University School of Medicine and University of Tartu. Prof. Santos research interests include the development of nanoparticles/nanomedicines and biomaterials for biomedical applications, particularly cancer and heart diseases. His lab makes the unique bridge between medical engineering, pharmaceutical nanotechnology and tissue engineering by combining unique techniques to develop novel therapeutic formulations for translation into the clinic. He is also in Editorial board member of several international journals, and Associate Editor of Nano Select, Smart Materials in Medicine, and Drug Delivery and Translational Research, among others. Prof. Santos has received prestigious awards/grants, for example, the "Talent Prize in Science" in 2010 attributed by the Portuguese Government, ERC Starting Grant in 2013 and ERC Proof-of-Concept Grant in 2018, Young Researcher Award in 2013 attributed by Faculty of Pharmacy, the Academy of Finland Award for Social Impact in 2016, and the CRS Young Investigator Award 2021.

Part I: Biological aspects and properties of nanomaterials for oral drug delivery 1. Oral drug delivery: overview2. Organization of the intestinal mucosa and barriers to oral drug delivery3. Nanomaterials for oral drug administration4. Mucoadhesive and mucus-penetrating polymers for drug delivery5. Size, shape and surface charge considerations of orally delivered nanomedicines6. Modified drug release: current strategies and novel technologies for oral drug delivery7. Delivery platforms for oral drug administration8. (Trans)Buccal drug delivery

Part II: Advanced technologies for oral delivery applications9. Spray drying for the formulation of oral drug delivery systems10. Microdevices to successfully deliver orally administered drugs11. Batch and microfluidic reactors in the synthesis of enteric drug carriers12. 3D printing in oral drug delivery

Part III: Methods for the evaluation of oral drug delivery systems13. 3D intestinal models towards a more realistic permeability screening14. In vitro relevant information for the assessment of nanoparticles for oral drug administration15. In vivo testing of orally delivered nanoparticles

Part IV: Pharmaceutical industry perspective16. Industrial perspectives and future of oral drug delivery