RNA Metabolism and Gene Expression in Archaea

Béatrice Clouet-d'Orval, is a Research Director at the Centre de Biologie Intégrative, Toulouse (CBI/CNRS/Université de Toulouse). She received her degree in Genetics and Biochemistry from the Université Pierre et Marie Curie, Paris, and subsequently obtained an EMBO fellowship for postdoctoral research at the University of Colorado, Boulder. Béatrice Clouet-d'Orval believes that the emergence of model organisms permitting genome-wide approaches that allow for the study of RNA biology in Archaea represents a unique opportunity to obtain major insights into evolutionary conserved RNA processing pathways in the three domains of life. Her research interests include in vitro reconstitution of archaeal ribonucleoprotein complexes involved in tRNA modification, and identification and characterization of archaeal enzymes involved in RNA processing and degradation. In addition, she is also active in promoting networking between scientists working on RNA and Archaea.

I. RNA synthesis.- Systems approaches to genome occupancy and output of the archaeal transcription machinery.- Mechanisms of transcription regulation in archaea.- 2. RNAdegradingenzymes Archaeal Exosome.- RNA-degrading enzymes in Archaea.- 3.Translation, tRNA&rRNA processing.- Archaeal translation.- Life and Death of Ribosomes in Archaea.- Structure and Function of archaeal RNase P.- Complex Biosynthesis of N6-threonyl-carbamoyl adenosine - an anti-frameshift nucleoside.- 4.Non codingRNAs.- Evolution of C/D box sRNAs.- Computational Screens for C/D Box and H/ACA sRNAs, and Potential New Roles in Regulation.- Small non coding RNAs in methanogenic Archaea.- Small non coding RNAs in halophilic Archaea.- 5.CRISPR defense system.- CRISPR-Cas systems in Haloarchaea