Drug-Drug Interactions

Introducing Pharmacokinetics and Pharmacodynamic Concepts, M. Rowland

In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes, K.R. Korzekwa

Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions, S.E. Clarke and B.C. Jones

Review of Human UDP-Glucuronosyltransferases and Their Role in Drug-Drug Interactions, R.P. Remmel

Drug-Drug Interactions Involving the Membrane Transport Process, H. Kusuhara and Y. Sugiyama

In Vitro Models for Studying Induction of Cytochrome P450 Enzymes, J.M. Silva and D.A. Nicoll-Griffith

In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs, A. Madan, E. Usuki, L.A. Burton, B.W. Ogilvie, and A. Parkinson

The Role of P-Glycoprotein in Drug Disposition: Significance to Drug Development, M.D. Troutman, G. Luo, L.-S. Gan, and D.R. Thakker

The Role of the Gut Mucosa in Metabolically Based Drug-Drug Interactions, K.E. Thummel and D.D. Shen

Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro-In Vivo Correlations, D.R. Jones and S.D. Hall

Prediction of Metabolic Drug Interactions: Quantitative or Qualitative? J.H. Lin and P.G. Pearson

In Vivo Probes for Studying Induction and Inhibition of Cytochrome P450 Enzymes in Humans, G.R. Wilkinson

Molecular Modeling Approaches to Predict Drug Metabolism and Toxicity, A.M. ter Laak, M.J. de Groot, and N.P.E. Vermeulen

Development of a Metabolic Drug Interaction Database at the University of Washington, S.P. Carlson, I. Ragueneau-Majlessi, T.E. Bougan, and R.H. Levy

Drug-Drug Interactions: Clinical Perspective, D.J. Greenblatt and L.L. von Moltke

Drug-Drug Interactions: Toxicological Perspectives, S.D. Nelson

An Integrated Approach to Assessing Drug-Drug Interactions: A Regulatory Perspective, S.-M. Huang, P. Honig, L.J. Lesko, R. Temple, and R. Williams

Drug-Drug Interactions: Marketing Perspectives, K.J. Petty and J.M. Vega

Index