Bioinformatics and Molecular Evolution (eBook)

Paul Higgs is currently the Canada Research Chair in Biophysics at McMaster University. Previously, he was the course director of the Bioinformatics MSc at Manchester University. He has a PhD in statistical physics from the University of Cambridge. His current research interests include RNA structure and sequence evolution, molecular phylogenetics, theoretical evolutionary biology, and population genetics. Teresa Attwood is Professor of Bioinformatics at Manchester University, Visiting Fellow at the European Bioinformatics Institute, and author of the PRINTS protein fingerprint database. She has a PhD in biophysics from the University of Leeds, and now teaches national and international courses in bioinformatics. Her current research interests include protein sequence analysis, data visualization, and biomedical text mining.

Preface.

Chapter Plan.

Chapter 1. Introduction: The Revolution in Biological
Information.

Chapter 2. Nucleic Acids, Proteins, and Amino Acids.

Chapter 3. Molecular Evolution and Population Genetics.

Chapter 4. Models of Sequence Evolution.

Chapter 5. Information Resources for Genes and Proteins.

Chapter 6. Sequence Alignment Algorithms.

Chapter 7. Searching Sequence Databases.

Chapter 8. Phylogenetic Methods.

Chapter 9. Patterns in Protein Families.

Chapter 10. Probabilistic Methods and Machine Learning.

Chapter 11. Further Topics in Molecular Evolution and
Phylogenetics.

Chapter 12. Genome Evolution.

Chapter 13. DNA Microarrays and the 'omes.

Mathematical Appendix.

List of Web address.

Glossary.

Index.