Chromosomes (eBook)

Integrating classical knowledge of chromosome organisation with
recent molecular and functional findings, this book presents an
up-to-date view of chromosome organisation and function for
advanced undergraduate students studying genetics. The organisation
and behaviour of chromosomes is central to genetics and the equal
segregation of genes and chromosomes into daughter cells at cell
division is vital. This text aims to provide a clear and
straightforward explanation of these complex processes.

Following a brief historical introduction, the text covers the
topics of cell cycle dynamics and DNA replication; mitosis and
meiosis; the organisation of DNA into chromatin; the arrangement of
chromosomes in interphase; euchromatin and heterochromatin;
nucleolus organisers; centromeres and telomeres; lampbrush and
polytene chromosomes; chromosomes and evolution; chromosomes and
disease, and artificial chromosomes. Topics are illustrated with
examples from a wide variety of organisms, including fungi, plants,
invertebrates and vertebrates. This book will be valuable resource
for plant, animal and human geneticists and cell biologists.

Originally a zoologist, Adrian Sumner has spent over 25 years
studying human and other mammalian chromosomes with the Medical
Research Council (UK). One of the pioneers of chromosome banding,
he has used electron microscopy and immunofluorescence to study
chromosome organisation and function, and latterly has studied
factors involved in chromosome separation at mitosis. Adrian is an
Associate Editor of the journal Chromosome Research, acts as a
consultant biologist and is also Chair of the Committee of the
International Chromosome Conferences.

* * The most up-to-date overview of chromosomes in all their
forms.

* Introduces cutting-edge topics such as artificial chromosomes
and studies of telomere biology.

* Describes the methods used to study chromosomes.

* The perfect complement to Turner.