Electrospray and MALDI Mass Spectrometry (eBook)

RICHARD B. COLE, PHD, is a University Research Professor in The Department of Chemistry at The University of New Orleans. He has spent more than twenty-five years working in the field of mass spectrometry. His research interests include analytical/bio-organic chemistry as well as fundamentals and applications of mass spectrometry, with a focus on the development of novel analytical methods employing electrospray and MALDI.

Foreword: Desorption Ionization and Spray Ionization: Connections
and Progress (R. Graham Cooks).

Foreword to the First Edition (John B. Fenn).

Preface (Richard B. Cole).

Contributors.

Part I Fundamentals of ES.

1. On the Mechanism of Electrospray Ionization Mass Spectrometry
(ESIMS) (Paul Kebarle and Udo H. Verkerk).

2. Selectivity in Electrospray Ionization Mass Spectrometry
(Nadja B. Cech and Christie G. Enke).

3. Electrochemistry of the Electrospray Ion Source (Gary J.
Van Berkel and Vilmos Kertesz).

4. ESI Source Design (Andries P. Bruins).

Part II Fundamentals of MALDI.

5. MALDI Ionization Mechanisms: an Overview (Richard
Knochenmuss).

6. The Development of Matrix-Assisted Laser
Desorption/Ionization Sources (Peter B. O'Connor).

7. A Comparison of MALDI Matrices (Mahmud Hossain and Patrick
A. Limbach).

8. MALDI Imaging Mass Spectrometry (Alain Brunelle and
Olivier Laprévote).

Part III ES and MALDI Coupling to Mass Spectrometry
Instrumentation.

9. Coupling ESI and MALDI Sources to the Quadrupole Mass Filter,
Quadrupole Ion Trap, Linear Quadrupole Ion Trap, and Orbitrap Mass
Analyzers (Mark E. Bier).

10. Time-of-Flight Mass Spectrometry (Robert J.
Cotter).

11. Fourier Transform Ion Cyclotron Resonance and Magnetic
Sector Analyzers for ESI and MALDI (Jeremy J. Wolff and I.
Jonathan Amster).

12. Ion Mobility-Mass Spectrometry (John A. McLean, J.
Albert Schultz, and Amina S. Woods).

Part IV Practical Aspects of ES and MALDI.

13. ESI, APCI, and MALDI A Comparison of the Central Analytical
Figures of Merit: Sensitivity, Reproducibility, and Speed
(Thomas R. Covey, Bradley B. Schneider, Hassan Javaheri, J.C.
Yves LeBlanc, Gordana Ivosev, Jay J. Corr, and Peter
Kovarik).

14. Charge State Distributions in Electrospray and MALDI (Yan
Li and Richard B. Cole).

15. Probing Noncovalent Interactions by Electrospray Ionization
and Matrix-Assisted Laser Desorption/Ionization (Sonal Mathur,
Alexis Nazabal, and Renato Zenobi).

16. Ion Activation Methods for Tandem Mass Spectrometry
(Kristina H& #229;akansson and John S.
Klassen).

17. Dissociation of Even-Electron Ions (Carlos Afonso,
Richard B. Cole, and Jean-Claude Tabet).

Part V Biological Applications of ES and MALDI.

18. The Role of Mass Spectrometry for Peptide, Protein, and
Proteome Characterization (A. Jimmy Ytterberg, Jason Dunsmore,
Shirley H. Lomeli, Mario Thevis, Yongming Xie, Rachel R. Ogorzalek
Loo, and Joseph A. Loo).

19. Carbohydrate Analysis by ESI and MALDI (David J.
Harvey).

20. Applications of ESI and MALDI to Lipid Analysis (Xianlin
Han).

21. In Vitro ADME Profiling and Pharmacokinetic Screening in
Drug Discovery (Daniel B. Kassel).

Index.

"Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, this volume will help researchers fully leverage the power
of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry". (Anticancer Research, 1 August 2010)