Miniaturization of Analytical Systems (eBook)

Angel Rios is Professor of Analytical Chemistry and the University of Castilla-La Mancha in Spain. Dr Alberto Escarpa, Univeristy of Alcals, Alcala de Henares, Spain. Dr Bartolomoe M Simonet, University of the Balearic Islands, Spain.

Preface.

1 Miniaturization in Analytical Chemistry.

1.1 Introduction.

1.2 Miniaturization as One of the Critical Trends in ModernAnalytical Chemistry.

1.3 Evolution in the Field of Analytical Miniaturization.

1.4 Classification of Miniaturized Analytical Systems andDefinition of Terms.

1.5 Theory of Miniaturization.

1.6 Features of Miniaturized Analytical Systems.

1.7 Incidences of Miniaturization in the Analytical Process.

1.8 Outlook.

References.

2 Tools for the Design of Miniaturized AnalyticalSystems.

2.1 Introduction.

2.2 Miniaturized Analytical Processes: The Downsizing andIntegrating Phenomena.

2.3 Microfluidic Devices.

2.4 Microtechnology.

2.5 MEMS and NEMS.

2.6 Outlook.

References.

3 Automation and Miniaturization of Sample Treatment.

3.1 Introduction.

3.2 Simplification of Sample Treatment: MicroextractionTechniques.

3.3 Simplification of Sample Treatment: Continuous FlowSystems.

References.

4 Miniaturized Systems for Analytical Separations I: SystemsBased on a Hydrodynamic Flow.

4.1 Introduction.

4.2 The Earliest Example of Miniaturization of a GasChromatograph and Some Other Developments.

4.3 Capillary Liquid Chromatography (CLC).

4.4 Liquid Chromatography on Microchips.

References.

5 Miniaturized Systems for Analytical Separations II: SystemsBased on Electroosmotic Flow (EOF).

5.1 Introduction.

5.2 CE on the Microchip Format.

5.3 Modes and Theories of CE Microchips.

5.4 Microfabrication Techniques.

5.5 Basic Fluidic Manipulation/Motivation: ElectrokineticInjection and Separation Protocols.

5.6 Electrochromatography in Microchip Format: Designs andApplications.

5.7 Comparison of Hydrodynamic and Electroosmotic Flow-drivenMiniaturized Systems.

5.8 Analytical Applications.

5.9 Outlook.

References.

6 Detection in Miniaturized Analytical Systems.

6.1 Introduction.

6.2 Laser-induced Fluorescence (LIF) Detection.

6.3 Electrochemical Detection (ED).

6.4 Microfluidics-MS Interfacing.

6.5 Unconventional Detection Methods.

6.6 Outlook.

References.

7 Miniaturization of the Entire Analytical Process I:Micro(nano)sensors.

7.1 Introduction.

7.2 Evolution of Sensors with Nanotechnology.

7.3 Micro(nano)sensors.

7.4 Nanoprobes for In Vivo Bioanalysis.

References.

8 Miniaturization of the Entire Analytical Process II: MicroTotal Analysis Systems (muTAS).

8.1muTAS, Microfluidics and Lab-on-a-Chip: Conceptsand Terminology.

8.2 Basic Concepts of Microfluidics: The Design of AnalyticalMicrosystems.

8.3 The Basics of Downscaling in Microsystems.

8.4 Microfluidic Platforms: Types, Principles andClassification.

8.5 Microfluidic Devices for Analytical Lab-on-a-ChipApplications.

8.6 Outlook.

References.

9 Portability of Miniaturized Analytical Systems.

9.1 Introduction.

9.2 Portable Gas Analysers.

9.3 Portable Electrochemical Analysers.

9.4 Portable Optical Analysers.

9.5 Portable Lab-on-a-Chip Analysers.

References.

10 Analytical Performance of Miniaturized AnalyticalSystems.

10.1 Introduction.

10.2 Quality Control in Miniaturized Systems.

10.3 Validation of Microsystems.

10.4 Qualification of Microsystems.

10.5 Robustness of Microsystems.

Further Reading.

Index.

"There is a good balance among the different topics dealt with as
well as among the theoretical background, the description of the
miniaturized systems and their practical applications. No doubt,
the book will be very valuable for researchers, students and
teachers of analytical chemistry because it represents the
immediate future of this discipline." (Zentralblatt Math,
2010)



"The authors have achieved a very nice mix of theoretical
discussions and the use of equations, graphs and tables to make
points and give comparisons. They also use photographs well and do
no over-populate pages with photograph after photograph. Overall,
they have made this into a readable book and also a good initial
reference book." (Chromatographia, 22 January 2011)

"The book is comprehensive and clearly written. There is a good
balance among the different topics dealt with as well as among the
theoretical background, the description of the miniaturized systems
and their practical applications." (Analytical and
Bioanalytical Chemistry, Jan - June 2010)