Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease O–BK

NATANYA CIVJAN, PhD, is a freelance editor with a doctorate in biochemistry. Formerly with John Wiley & Sons, she developed and edited the Wiley Encyclopedia of Chemical Biology and was part of the team responsible for the Wiley Interdisciplinary Reviews, which won top prizes in publishing from the American Publishers Awards for Professional and Scholarly Excellence.

Contributors xi PART I DRUG DISCOVERY AND DEVELOPMENT 1 1 The Role of Chemical Biology in Drug Discovery 3 Andrew J. Pope 2 Computational Approaches to Drug Discovery and Development 23 Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu, and Hualiang Jiang 3 Design and Selection of Small Molecule Inhibitors 41 Jianwei Che, Yi Liu, and Nathanael S. Gray 4 Lead Optimization in Drug Discovery 65 Craig W. Lindsley, David Weaver, Thomas M. Bridges, and J. Phillip Kennedy 5 Pharmacokinetics of Drug Candidates 83 Ronald E. White 6 ADME Properties of Drugs 101 Li Di and Edward H. Kerns 7 Drug Transport in Living Systems 115 Yael Elbaz and Shimon Schuldiner 8 Blood-Brain Barrier: Considerations in Drug Development and Delivery 133 David S. Miller and Brian T. Hawkins 9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery 147 Zhong Zuo and Vincent H. L. Lee 10 Pharmaceuticals: Natural Products and Natural Product Models 165 Sheo B. Singh PART II CHEMICAL BIOLOGY TO UNDERSTAND AND TARGET DISEASE 203 11 The Role of Chemical Biology in Understanding and Treating Disease--Are Small Molecule "Correctors" the Way of the Future? 205 David Selwood 12 Anxiety Disorders 215 Miklos Toth 13 Chronic Obstructive Pulmonary Disease (COPD) 245 Peter J. Barnes 14 Depression 267 Glen B. Baker and Nicholas D. Mitchell 15 Osteoarthritis 293 Marjolaine Gosset, Jeremie Sellam, Claire Jacques, nd Francis Berenbaum 16 Human Immunodeficiency Virus (HIV) 331 Joseph P. Vacca 17 Allergy and Asthma 341 Garry M. Walsh 18 Schizophrenia 357 Ferenc Martenyi 19 Protein Misfolding and Disease 379 Johanna C. Scheinost, Grant E. Boldt, and Paul Wentworth 20 Protein Trafficking Diseases 401 Heidi M. Sampson and David Y. Thomas 21 Metabolic Diseases 419 Cynthia M. Arbeeny 22 Mitochondrial Medicine 445 Richard J. T. Rodenburg and Jan A. M. Smeitink 23 Lysosomal Disorders 461 Doug A. Brooks and Maria Fuller Index 483