Radiation Health Risk Sciences (eBook)

Acknowledgments 5
Organizing Committee 6
Preface 8
Greetings 10
Addresses 12
Contents 19
Contributors 24
Global Strategic Center for Radiation Health Risk Control 35
Discussion on Points of Radiation Safety and the Scope of The University of Tokyo Global COE Program 44
Network System for Radiation Emergency Medicine in Japan and the Role of Hiroshima University 54
Non-DNA-Targeted Effects and Low-Dose Radiation Risk 60
Update from the Chernobyl Tissue Bank: Effect of Latency on Different Types of Thyroid Cancer Post-Chernobyl 65
Current Risk Estimate of Radiation-Related Cancer and Our Insight into the Future 74
Introduction of Atomic Bomb Disease Medical Research in Global COE Program 81
The Offspring of Atomic Bomb Survivors: Cancer and Non-Cancer Mortality and Cancer Incidence 87
Ischemic Heart Disease Among Atomic Bomb Survivors: Possible Mechanism(s) Linking Ischemic Heart Disease and Radiation Exposure 93
Leukemia, Lymphoma, and Multiple Myeloma Incidence in the LSS Cohort: 1950–2001 99
Follow-Up Study of 78 Healthy Exposed Atomic Bomb Survivors for 35 Years in Hiroshima, with Special Reference to Multiple Cancers 104
Research Activities and Projects Within a Framework of International Radiation Health Sciences Research 110
Age and Prognosis: Do Adjuvant Therapies In.uence the Real Prognosis? 119
Mortality of the Chernobyl Emergency Workers: Analysis of Dose Response by Cohort Studies Covering Follow-Up Period of 1992–2006 124
Twenty Years After Chernobyl: Implications for Radiation Health Risk Control 132
Fallout Exposure of the Population and Thyroid Nodular Diseases 142
Higher-Order Chromatin Structure and Nontargeted Effects 150
p53 Dependency of Delayed and Untargeted Recombination in Mouse Embryos Fertilized by Irradiated Sperm 154
The Yin and Yang of Low-Dose Radiobiology 162
Induction and Persistence of Cytogenetic Damage in Mouse Splenocytes Following Whole-Body X-Irradiation Analysed by Fluorescence In Situ Hybridisation. V. Heterogeneity/Chromosome Speci.city 170
Molecular Understanding of RET/PTC-Mediated Thyroid Carcinogenesis 178
Molecular Prediction of Therapeutic Response and Adverse Effect of Chemotherapy in Breast Cancer 202
Multiple Roles of NBS1 for Genotoxic and Nongenotoxic Stresses 208
The DNA Damage Response in Nontargeted Cells 216
The Role of Telomere Dysfunction in Driving Genomic Instability 222
Secretory Clusterin Is a Marker of Tumor Progression Regulated by IGF-1 and Wnt Signaling Pathways 227
Target of Radiation Carcinogenesis Is Protein: Becoming Triploid Is Proximate Cause of Cell Transformation 235
Adult Stem Cells, the Barker Hypothesis, Epigenetic Events, and Low-Level Radiation Effects 239
Combined Effect of Ionizing Radiation and N-Ethyl-N-Nitrosourea on Mutation Induction and Lymphoma Development 250
g-Ray-Induced Mouse Thymic Lymphomas: Bcl11b Inactivation and Prelymphoma Cells 255
Framework of Radiation Safety Management in Japan: Laws, Administrative Agencies, and Supporting Associations 264
Background Radiation Dose to the Population Around the Kudankulam Nuclear Power Plant 269
International Cooperation in Radiation Emergency Medical Preparedness: Establishment of a Medical Network in Asia 275
Long-Term Biopsychosocial Consequences of Disaster: Focus on Atomic Bomb Survivors 282
Health Status of Children Exposed to the Chernobyl Accident In Utero: Observations in 1989–2003 and the Implications for Prioritizing Prophylactic Programs 290
Psychological Consequences More Than Half a Century After the Nagasaki Atomic Bombing 296
Signi.cance of Oncogene Ampli.cations in Breast Cancer in Atomic Bomb Survivors: Associations with Radiation Exposure and Histological Grade 303
Paracrine Interactions Between Normal, but Not Cancer, Epithelial and Normal Mesenchymal Cells Attenuate Radiation-Induced DNA Damage 312
Thyroid Cancer in Ukraine After the Chernobyl Accident: Incidence, Pathology, Treatment, and Molecular Biology 321
Current Trends in Incidence and Mortality from Thyroid Cancer in Belarus 333
The Health Status of the Population in the Semey Region and Scienti.cally Proven Measures to Improve It 338
Nuclear Explosions and Public Health Development 344