ABC Proteins

By I Barry Holland

Preface. Introduction. PART 1-PHYLOGENY AND EVOLUTION OF ABC-TRANSPORTERS Phylogenetic and Functional Classification of ABC (ATP-binding cassette) Systems Membrane Topology of the Human ABC Transporter Proteins Human and Drosophila ABC-Proteins PART 2-FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC-TRANSPORTERS Structure and Modular Organization of ABC-Transporters Substrate Binding Sites in ABC-Transporters Probing of Conformational Changes,Catalytic Cycle and ABC-Transporters Function X-ray Structure of an Intact ABC-Transporter, MsbA PART 3-PROKARYOTE ABC-TRANSPORTERS Introduction to Bacterial ABC-Transport Systems Import of Solutes by ABC-Transporters-The Maltose System Crystal Structures of Periplasmic Solute Binding Proteins in ABC-Transport Complexes Illuminate their Function Bacterial ABC-Transporters Involved in Protein Translocation Bacterial Multidrug Resistance Mediated by ABC-Transporters Structure and Function of Osmoregulated ABC Transporters PART 4 -NON-MAMMALIAN EUKARYOTE ABC-TRANSPORTERS Inventory & Evolution of Fungal ABC Protein Genes. Fungal ABC Proteins in Clinical Drug Resistance & Cellular Detoxification Drug Resistance Mediated by ABC Transporters in Parasites of Humans The Plant ABC Transporter Superfamily: the Functions of a Few and Identities of Many PART 5-MAMMALIAN MULTIDRUG RESISTANCE ABC-TRANSPORTERS Solving the Problem of Multidrug Resistance: ABC Transporters in Clinical Oncology Multidrug Resistance Protein 1 (ABCC1) MRP2, the Apical Export Pump for Anionic Conjugates The Multidrug Resistance Proteins 3-7 Lipid Transport by ABC Transporters Role of ABCA1 in Cell Turnover and Lipid Homeostasis Peroxisome ABC-Transporters ABC-Transporters in Mitochondria The Transporter Associated with Antigen Processing (TAP): A Peptide Transport and Loading Complex Essential for Cellular Immune Responses The Sulphonylurea Receptor: an ABCC Transporter that Acts as an Ion Channel Regulator ABC-Transporters and Human Eye Disease Structure Function Analysis of CFTR