Hepatotoxicity

Part 1 General considerations: the spectrum of hepatotoxicity; hepatic metabolism of foreign compounds; vulnerability of the liver to toxic injury; expressions of hepatotoxicity; classification of hepatotoxins and mechanisms of toxicity; hepatotoxic effects of ethanol; chemical hepatocarcinogenesis. Part 2 Experimental hepatotoxicity: experimental hepatotoxicity; direct hepatotoxins - haloaliphatics, phosphorus, iron and copper; indirect cytotoxic hepatotoxins; toxic cholestasis. Part 3 Environmental hepatotoxicity: syndromes of environmental hepatotoxicity; occupational toxicity; hepatotoxicity in the household; the hepatotoxic potential of a polluted environment. Part 4 Iatrogenic hepatic injury: drug-induced liver disease; anaesthetic agents; psychotropic and anticonvulsant agents; drugs used to treat rheumatic and musculospastic disease; hormonal derivatives and related drugs; hepatic injury from the treatment of infectious and parasitic diseases; drugs used in cardiovascular disease; hepatotoxic effects of oncotherapeutic and immunosuppressive agents; miscellaneous drugs and diagnostic chemicals; afterthoughts on hepatotoxicity; appendices.