Clinical Immunobiology (eBook)

Front Cover 
1 
Clinical Immunobiology 4
Copyright Page 5
Table of Contents 6
List of Contributors 12
Preface 16
Contents of Previous Volumes 20
Chapter 1. General Orientation of Human Lymphocyte Subpopulations 26
I. Introduction 27
II. Cytoplasmic Immunoglobulin 30
III. Membrane Immunoglobulin 31
IV. la System 34
V. Epstein-Barr Virus (EBV) Receptor 37
VI. Complement Receptors 38
VII. Receptors for Fc Region of Immunoglobulins 39
VIII. Enzymatic Markers 42
IX. Receptors for Peanut Agglutinin 43
X. Erythrocyte Receptors 44
XI Surface Antigens of Lymphocyte Subpopulations Defined by Monoclonal Antibodies 46
XII. Relationship between Ty Cells and Monocytes 51
XIII. Distinction of Lymphocytes from Monocytes 53
XIV. The Third-Cell Population or Unclassified Lymphoid Cells 54
XV. Summary 55
References 55
Chapter 2. Lymphocyte Membrane Complement Receptors 58
I. Introduction 58
II. Methods for Detection of C Receptors 62
III. Expression of C Receptors and Other Surface Markers on Normaland Leukemic Human Lymphocytes 65
IV. Interpretation and Significance 67
References 70
Chapter 3. Regulatory Human T-Cell Subpopulations Defined by Receptors for IgG or IgM 72
I. Introduction 72
II. Enumeration and Isolation of T.M and T.G Cells 73
III. Morphology of T.M and T.G Cells 74
IV. Tissue Distribution of T.M and T.G Cells 75
V. Functional Analysis of T.M and T.G Cells 75
VI. Clinical Relevance of T.M and T.G Subpopulations 77
Selected Reading 78
Addendum 78
Chapter 4. Mitogens 80
I. Introduction 80
II. Fundamentals of Lectin-Induced Mitogenesis 82
III. Procedure for Determining in Vitro Lectin-induced Activation of Lymphocytes 87
IV. Clinical Usefulness of Lectins 90
General Reading References 97
Chapter 5. Natural Killer Cells and Cells Mediating Antibody-Dependent Cytotoxicity against Tumors 98
I. Introduction 98
II. Methods 99
III. Characteristics of NK Cells and Their Relationship to K Cells 102
IV. Specificity of Natural Cytotoxicity 104
V. Factors Affecting Levels of NK and K Cell Activities 107
VI. Possible Clinical Significance of These Effector Cells 109
References 111
Chapter 6. Regulation of the Immune System by Lymphocyte Sets: Analysis in Animal Models 114
I. General Considerations 114
II. Analysis in the Mouse 116
III. Conclusions 120
Selected References 122
Chapter 7. The Serology of HLA-A, -B, and -C 124
I. Introduction 124
II. Experimental Methods and Findings 125
III. Conclusions 134
References 136
Chapter 8. The Serology of HLA-DR 138
I. Introduction 138
II. Technical Considerations 139
III. Results 143
IV. Discussion 145
References 146
Chapter 9. Cellular Immunogenetics—Definition of HLA-D Region Encoded Antigens by T Lymphocyte Reactivities 148
I. Introduction 149
II. Mixed Leukocyte Culture with Homozygous Typing Cells 152
III. Primed LD-Typing (PLT) 157
IV. General Discussion 166
References 167
Chapter 10. Cell-Mediated Lympholysis 168
I. Introduction 168
II. Terminology 170
III. Technique 171
V. Genetic Control of CML 173
VI. Cell-Mediated Lympholysis Typing 176
VII. Preliminary Information from CML Typing Experiments 182
VIII. Future Prospects 183
Suggested Reading List 185
Chapter 11. HLA and Graft Survival 186
I. Introduction 186
II. Methodology 189
III. Results 191
References 196
Chapter 12. HLA and Disease 198
I. Introduction 198
II. Methods 199
III 
200 
IV. Disease Heterogeneity 201
V. Inheritance of Disease Susceptibility and Resistance 202
VI. Mechanisms that Can Explain the Associations 204
VII. Diagnostic and Prognostic Value 205
Acknowledgments 206
Key References 206
Chapter 13. Other Markers in the HLA Linkage Group 208
I. Introduction 208
II. Genetic Considerations 210
III. Other Markers in the HLA Linkage Group 211
IV. Complement Components 212
V. Intracellular Enzymes 216
VI. Concluding Remarks 218
Selected References 219
Index 220