Host Defenses to Intracellular Pathogens

and Historical Perspective.- I. Microbicidal Mechanisms of Leukocytes in Host Defenses.- Oxygen Independent Microbicidal Mechanisms of Human Polymorphonuclear Leukocytes.- Oxidative Metabolism of Leukocytes and Its Relationship to Bactericidal Activity.- Some Paradoxes of Macrophage Function.- Genetic Disorders of Granulocyte Function: What They Tell Us About Normal Mechanisms.- II. The Immune System and Phagocytic Cell Function.- Modulation of Effector Lymphokines.- Stimulation of Host Resistance to Metastatic Tumors by Macrophage Activating Agents Encapsulated in Liposomes.- Effect of Prostaglandins on the Production of Interleukin-2.- Interaction of Mycobacteria with Normal and Immunologically Activated Alveolar Macrophages.- Guinea Pig Alveolar Macrophages Probably Kill M. tuberculosis H37Rv and H37Ra in vivo by Producing Hydrogen Peroxide.- Interferon and Host Defense Systems.- Mediator Interactions Regulating Macrophage Secretion of Interleukin 1 and Interferon.- Macrophage Oxygen-Dependent Killing of Intracellular Parasites: Toxoplasma and Leishmania.- Immunologic Lesions During Toxoplasma gondii Infection.- Immunodepression in BALB/c Mice Infected with Leishmania tropica.- III. Host Defenses to Intracellular Bacteria.- Cellular Mechanisms of Anti-Mycobacterial Immunity.- Host Response to Infection with Mycobacterium bovis (BCG) in Mice: Genetic Study of Natural Resistance.- Cell Mediated Lysis of Lymphocytes Expressing Bacterial Antigens.- Improvement of Abnormal Lymphocyte Responses in “Atypical” Mycobacteriosis with Indomethacin.- Immunoregulatory Defects in Leprosy.- Cellular Mechanisms of Resistance to Listeria monocytogenes.- Effect of Interferon Inducers and Purified Mouse Interferon on the Susceptibility of Mice to Infection with Listeriamonocytogenes.- Natural Resistance to Listeria monocytogenes as a Function of Macrophage Inflammatory Response.- Effect of Acute Nutritional Deprivation on Host Defenses Against Listeria monocytogenes — Macrophage Function.- Pilus-Mediated Clearance of Salmonella typhimurium by the Perfused Mouse Liver.- Immunity to Salmonella Infection.- Strain Dependent Variation of Delayed-Type Hypersensitivity in Salmonella typhimurium Infected Mice.- Monoclonal Antibodies to Salmonella typhimurium and Escherichia coli Lipopolysaccharides.- Characterization of Monoclonal Antibodies Which Recognize Specific Cell Surface Determinants on Salmonella typhimurium.- Monoclonal Antibodies as Probes for Antigens of Mycoplasma pulmonis.- Electron Microscopic Examination of the Inflammatory Response of Guinea Pig Neutrophils and Macrophages to Legionella pneumophila.- IV. Immunity to Rickettsia, Parasites and Fungi.- Activation of Macrophages for Killing of Rickettsiae: Analysis of Macrophage Effector Function After Rickettsial Inoculation of Inbred Mouse Strains.- Parameters of Cellular Immunity in Acute and Chronic Rickettsia tsutsugamushi Infections of Inbred Mice.- Lymphokine Stimulated Macrophages Inhibit Intracellular Chlamydia psittaci Replication by Mechanisms Distinct from Intracellular Inhibition of Toxoplasma gondii Replication.- Natural and Acquired Resistance to Trypanosoma cruzi.- Immunity to Fungal Infections.- Antibody-Independent Mechanisms in the Development of Acquired Immunity to Malaria.- Intracellular Destruction of Leishmania tropica by Macrophages Activated In Vivo with Mycobacterium bovis Strain BCG.- In Vitro Macrophage Antimicrobial Activities and In Vivo Susceptibility to Leishmania tropica Infection.- V. Mechanisms of Antiviral Immunity.- Virus-Immune T Cellsand Monoclonal Antibodies in the Mouse Influenza Model.- Escape from Immune Surveillance During Persistent Virus Infection.- Influence of Viruses on Cells of the Immune Response System.- Genetically Controlled Resistance to Viruses.- Macrophage Oxidative Metabolism: A Defense Mechanism Against virus Infection?.- Interferon-Induced Augmentation of Natural Killer Cell Activity by Splenocytes from Leukemia Virus Immunosuppressed Mice.- Immunological Comparison of Ocular Disease Induced by Two Strains of Herpes Virus of Different Virulence.- Cellular Processing of the Large Glycoprotein of Lacrosse Virus (Family Bunyaviridae); Implications for Virion Assembly and Host Defense.- CMV and Renal Allograft Survival.- Martyrs, A Poem by Dr. L. J. Berry.- Contributors.- Author Index.