Progress in Radiopharmacy

I. Generator Systems for Ultra-Short-Lived Radionuclides.- Generators for ultra-short-lived radionuclides. Their potential and limitations.- The current status of the Os-191?Ir-191m generator.- Pharmaceutical aspects of Krypton-81m generators.- The Yttrium-87/Strontium-87m generator. A new approach to its preparation.- II. Positron Emitting Radiopharmaceuticals.- Positrons from generators.- Production of positron emitting radionuclides using cyclotrons.- III. Radiochemistry.- Cu(I) supported isotopic exchange of arylbound iodide, new future for fast high yield labelling.- Iodine labelled 5-iodo-2-thiouracil as a melanoma seeking agent: a potential drug for diagnosis and treatment.- The synthesis and biodistribution of a radioiodinated GM1 ganglioside derivative.- Advances in radiochemistry of Tc-99m.- New aspects of complexation of technetium with DTPA ligand.- Indium chemistry in radiopharmaceutical development.- New radiohalogenation: an overview.- IV. Recent Developments in Radiopharmacy Practice.- Computers in radiopharmacy.- New developments in radiopharmacy. Dispensing techniques.- Radiopharmacy information and reporting systems. An overview.- Training and education of pharmacists for radiopharmacy.- Quality control of radiopharmaceuticals: Recent developments in analytical techniques.- A multicentre evaluation of techniques for determination of the radiochemical purity of Tc99m-DTPA.- Implications of new imaging techniques for radiopharmacy.- V. Biological Fate of Radiopharmaceuticals.- Biological fate of renal agents.- Tc99m bone seeking phosphate compounds: Studies on in vivo and in vitro behaviour.- Colloids for functional studies of the reticuloendothelial system. Quality control and biological behaviour.- In vivo behaviour of radiopharmaceuticals formyocardial imaging and metabolic studies.- Incorporation dosimetry of I-131-meta-iodobenzylguanidine (I-131-MIBG).- VI. Radionuclides in Drug Formulation Studies.- Radionuclides in drug formulation studies.- Syringe extractables: Effects on radiopharmaceuticals.- Radiolabelled antibodies as radiopharmaceuticals.- The radiolabelling of monoclonal antibodies with In-111 and their application in vivo for detection of thyroid metastases.- Production, quality control and clinical application of In-111-labelled anti-tumour monoclonal antibody.- Characterization of blood-borne radiolabel and detection of anti-mouse IgC antibodies in cancer patients receiving radiolabelled monoclonal antibody for diagnostic immunoscintigraphy.- Protein based radiopharmaceuticals: Applicability of polyacryl-amide gel electrophoresis in the quality control of labelled protein preparation.- VII. Radiopharmaceutical Aerosols.- Inhaled aerosols: Deposition and clearance.- Radioaerosols: Production and characteristics.- Lung perfusion then ventilation using a Tc-99m aerosol: Experiences with a commercial system.- Author index.